Non-Coding RNAs in multiple myeloma bone disease pathophysiology

Lavinia Raimondi, Angela De Luca, Gianluca Giavaresi, Stefania Raimondo, Alessia Gallo, Elisa Taiana, Riccardo Alessandro, Marco Rossi, Antonino Neri, Giuseppe Viglietto, Nicola Amodio

Research output: Contribution to journalReview articlepeer-review

Abstract

Bone remodeling is uncoupled in the multiple myeloma (MM) bone marrow niche, resulting in enhanced osteoclastogenesis responsible of MM-related bone disease (MMBD). Several studies have disclosed the mechanisms underlying increased osteoclast formation and activity triggered by the various cellular components of the MM bone marrow microenvironment, leading to the identification of novel targets for therapeutic intervention. In this regard, recent attention has been given to non-coding RNA (ncRNA) molecules, that finely tune gene expression programs involved in bone homeostasis both in physiological and pathological settings. In this review, we will analyze major signaling pathways involved in MMBD pathophysiology, and report emerging evidence of their regulation by different classes of ncRNAs.

Original languageEnglish
Article number37
JournalNon-coding RNA
Volume6
Issue number3
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Bone disease
  • Long non-coding RNA
  • MiRNA
  • Multiple myeloma
  • Non-coding RNA
  • Tumor microenvironment

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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