Non-familial hemophagocytic lymphohistiocytosis

C. Cozzutto, A. Carbone, A. Comelli, R. Volpe

Research output: Contribution to journalArticlepeer-review


A case of non-familial hemophagocytic lymphohistiocytosis (HLH) is described. The patient had a chronic course being alive and doing relatively well 3 years since onset. The specific pathological features of this disorder are discussed with emphasis on the fact that a remarkable loss of lymph node structure is sustained by a mature lymphohistiocytic infiltrate. Erythrophagocytosis is assessed as an important but not specific finding. Lymphocyte depletion is an important feature of the lesion. The presence of overlapping features in HLH, infection-associated hemophagocytic syndrome (IAHS) and X-linked recessive lymphoproliferative syndrome (XLS) is emphasized.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalPathology Research and Practice
Issue number3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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