Abstract
A case of non-familial hemophagocytic lymphohistiocytosis (HLH) is described. The patient had a chronic course being alive and doing relatively well 3 years since onset. The specific pathological features of this disorder are discussed with emphasis on the fact that a remarkable loss of lymph node structure is sustained by a mature lymphohistiocytic infiltrate. Erythrophagocytosis is assessed as an important but not specific finding. Lymphocyte depletion is an important feature of the lesion. The presence of overlapping features in HLH, infection-associated hemophagocytic syndrome (IAHS) and X-linked recessive lymphoproliferative syndrome (XLS) is emphasized.
| Original language | English |
|---|---|
| Pages (from-to) | 273-278 |
| Number of pages | 6 |
| Journal | Pathology Research and Practice |
| Volume | 184 |
| Issue number | 3 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
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Non-familial hemophagocytic lymphohistiocytosis. / Cozzutto, C.; Carbone, A.; Comelli, A.; Volpe, R.
In: Pathology Research and Practice, Vol. 184, No. 3, 1989, p. 273-278.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Non-familial hemophagocytic lymphohistiocytosis
AU - Cozzutto, C.
AU - Carbone, A.
AU - Comelli, A.
AU - Volpe, R.
PY - 1989
Y1 - 1989
N2 - A case of non-familial hemophagocytic lymphohistiocytosis (HLH) is described. The patient had a chronic course being alive and doing relatively well 3 years since onset. The specific pathological features of this disorder are discussed with emphasis on the fact that a remarkable loss of lymph node structure is sustained by a mature lymphohistiocytic infiltrate. Erythrophagocytosis is assessed as an important but not specific finding. Lymphocyte depletion is an important feature of the lesion. The presence of overlapping features in HLH, infection-associated hemophagocytic syndrome (IAHS) and X-linked recessive lymphoproliferative syndrome (XLS) is emphasized.
AB - A case of non-familial hemophagocytic lymphohistiocytosis (HLH) is described. The patient had a chronic course being alive and doing relatively well 3 years since onset. The specific pathological features of this disorder are discussed with emphasis on the fact that a remarkable loss of lymph node structure is sustained by a mature lymphohistiocytic infiltrate. Erythrophagocytosis is assessed as an important but not specific finding. Lymphocyte depletion is an important feature of the lesion. The presence of overlapping features in HLH, infection-associated hemophagocytic syndrome (IAHS) and X-linked recessive lymphoproliferative syndrome (XLS) is emphasized.
UR - http://www.scopus.com/inward/record.url?scp=0024524182&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024524182&partnerID=8YFLogxK
M3 - Article
VL - 184
SP - 273
EP - 278
JO - Pathology Research and Practice
JF - Pathology Research and Practice
SN - 0344-0338
IS - 3
ER -