Non-functioning pituitary adenoma database: A useful resource to improve the clinical management of pituitary tumors

Emanuele Ferrante, Monica Ferraroni, Tristana Castrignanò, Laura Menicatti, Mascia Anagni, Giuseppe Reimondo, Patrizia Del Monte, Donatella Bernasconi, Paola Loli, Marco Faustini-Fustini, Giorgio Borretta, Massimo Terzolo, Marco Losa, Alberto Morabito, Anna Spada, Paolo Beck-Peccoz, Andrea G. Lania

Research output: Contribution to journalArticle

Abstract

Objective: The long-term outcome of non-functioning pituitary adenoma (NFPA) patients is not clearly established, probably due to the low annual incidence and prolonged natural history of these rare tumors. The aim of this study was to evaluate clinical data at presentation and long-term post-surgery and radiotherapy outcome in a cohort of patients with NFPA. Design and methods: A computerized database was developed using Access 2000 software (Microsoft Corporation, 1999). Retrospective registration of 295 NFPA patients was performed in seven Endocrinological Centers of North West Italy. Data were analyzed by STATA software. Results: The main presenting symptoms were visual defects (67.8%) and headache (41.4%) and the most frequent pituitary deficit was hypogonadism (43.3%), since almost all tumors were macroadenomas (96.5%). Surgery was the first choice treatment (98% of patients) and total debulking was achieved in 35.5%. Radiotherapy was performed as adjuvant therapy after surgery in 41% of patients. At the follow-up, recurrence occurred in 19.2% of patients without post-surgical residual tumor after 7.5 ± 2.6 years, regrowth in 58.4% of patients with post-surgical remnant after 5.3 ± 4.0 years and residue enlargement in 18.4% of patients post-surgically treated with radiotherapy after 8.1 ± 7.3 years. Conclusions: Our database indicates that the goal of a definitive surgical cure has been achieved during the last decade in a low percentage of patients with NFPA. This tumor database may help to reduce the delay between symptom onset and diagnosis, to assess prognostic parameters for the follow-up of patients with different risk of recurrence and to define the efficacy and safety of different treatments and their association with mortality/morbidity.

Original languageEnglish
Pages (from-to)823-829
Number of pages7
JournalEuropean Journal of Endocrinology
Volume155
Issue number6
DOIs
Publication statusPublished - Dec 2006

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Pituitary Neoplasms
Databases
Radiotherapy
Software
Recurrence
Neoplasms
Hypogonadism
Residual Neoplasm
Italy
Headache
Therapeutics
Morbidity
Safety
Mortality
Incidence

ASJC Scopus subject areas

  • Endocrinology

Cite this

Non-functioning pituitary adenoma database : A useful resource to improve the clinical management of pituitary tumors. / Ferrante, Emanuele; Ferraroni, Monica; Castrignanò, Tristana; Menicatti, Laura; Anagni, Mascia; Reimondo, Giuseppe; Del Monte, Patrizia; Bernasconi, Donatella; Loli, Paola; Faustini-Fustini, Marco; Borretta, Giorgio; Terzolo, Massimo; Losa, Marco; Morabito, Alberto; Spada, Anna; Beck-Peccoz, Paolo; Lania, Andrea G.

In: European Journal of Endocrinology, Vol. 155, No. 6, 12.2006, p. 823-829.

Research output: Contribution to journalArticle

Ferrante, E, Ferraroni, M, Castrignanò, T, Menicatti, L, Anagni, M, Reimondo, G, Del Monte, P, Bernasconi, D, Loli, P, Faustini-Fustini, M, Borretta, G, Terzolo, M, Losa, M, Morabito, A, Spada, A, Beck-Peccoz, P & Lania, AG 2006, 'Non-functioning pituitary adenoma database: A useful resource to improve the clinical management of pituitary tumors', European Journal of Endocrinology, vol. 155, no. 6, pp. 823-829. https://doi.org/10.1530/eje.1.02298
Ferrante, Emanuele ; Ferraroni, Monica ; Castrignanò, Tristana ; Menicatti, Laura ; Anagni, Mascia ; Reimondo, Giuseppe ; Del Monte, Patrizia ; Bernasconi, Donatella ; Loli, Paola ; Faustini-Fustini, Marco ; Borretta, Giorgio ; Terzolo, Massimo ; Losa, Marco ; Morabito, Alberto ; Spada, Anna ; Beck-Peccoz, Paolo ; Lania, Andrea G. / Non-functioning pituitary adenoma database : A useful resource to improve the clinical management of pituitary tumors. In: European Journal of Endocrinology. 2006 ; Vol. 155, No. 6. pp. 823-829.
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abstract = "Objective: The long-term outcome of non-functioning pituitary adenoma (NFPA) patients is not clearly established, probably due to the low annual incidence and prolonged natural history of these rare tumors. The aim of this study was to evaluate clinical data at presentation and long-term post-surgery and radiotherapy outcome in a cohort of patients with NFPA. Design and methods: A computerized database was developed using Access 2000 software (Microsoft Corporation, 1999). Retrospective registration of 295 NFPA patients was performed in seven Endocrinological Centers of North West Italy. Data were analyzed by STATA software. Results: The main presenting symptoms were visual defects (67.8{\%}) and headache (41.4{\%}) and the most frequent pituitary deficit was hypogonadism (43.3{\%}), since almost all tumors were macroadenomas (96.5{\%}). Surgery was the first choice treatment (98{\%} of patients) and total debulking was achieved in 35.5{\%}. Radiotherapy was performed as adjuvant therapy after surgery in 41{\%} of patients. At the follow-up, recurrence occurred in 19.2{\%} of patients without post-surgical residual tumor after 7.5 ± 2.6 years, regrowth in 58.4{\%} of patients with post-surgical remnant after 5.3 ± 4.0 years and residue enlargement in 18.4{\%} of patients post-surgically treated with radiotherapy after 8.1 ± 7.3 years. Conclusions: Our database indicates that the goal of a definitive surgical cure has been achieved during the last decade in a low percentage of patients with NFPA. This tumor database may help to reduce the delay between symptom onset and diagnosis, to assess prognostic parameters for the follow-up of patients with different risk of recurrence and to define the efficacy and safety of different treatments and their association with mortality/morbidity.",
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AU - Ferrante, Emanuele

AU - Ferraroni, Monica

AU - Castrignanò, Tristana

AU - Menicatti, Laura

AU - Anagni, Mascia

AU - Reimondo, Giuseppe

AU - Del Monte, Patrizia

AU - Bernasconi, Donatella

AU - Loli, Paola

AU - Faustini-Fustini, Marco

AU - Borretta, Giorgio

AU - Terzolo, Massimo

AU - Losa, Marco

AU - Morabito, Alberto

AU - Spada, Anna

AU - Beck-Peccoz, Paolo

AU - Lania, Andrea G.

PY - 2006/12

Y1 - 2006/12

N2 - Objective: The long-term outcome of non-functioning pituitary adenoma (NFPA) patients is not clearly established, probably due to the low annual incidence and prolonged natural history of these rare tumors. The aim of this study was to evaluate clinical data at presentation and long-term post-surgery and radiotherapy outcome in a cohort of patients with NFPA. Design and methods: A computerized database was developed using Access 2000 software (Microsoft Corporation, 1999). Retrospective registration of 295 NFPA patients was performed in seven Endocrinological Centers of North West Italy. Data were analyzed by STATA software. Results: The main presenting symptoms were visual defects (67.8%) and headache (41.4%) and the most frequent pituitary deficit was hypogonadism (43.3%), since almost all tumors were macroadenomas (96.5%). Surgery was the first choice treatment (98% of patients) and total debulking was achieved in 35.5%. Radiotherapy was performed as adjuvant therapy after surgery in 41% of patients. At the follow-up, recurrence occurred in 19.2% of patients without post-surgical residual tumor after 7.5 ± 2.6 years, regrowth in 58.4% of patients with post-surgical remnant after 5.3 ± 4.0 years and residue enlargement in 18.4% of patients post-surgically treated with radiotherapy after 8.1 ± 7.3 years. Conclusions: Our database indicates that the goal of a definitive surgical cure has been achieved during the last decade in a low percentage of patients with NFPA. This tumor database may help to reduce the delay between symptom onset and diagnosis, to assess prognostic parameters for the follow-up of patients with different risk of recurrence and to define the efficacy and safety of different treatments and their association with mortality/morbidity.

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