Non-G cell gastrin-producing tumours of the pancreas

G. Vassallo, E. Solcia, G. Bussolati, Julia M. Polak, A. G E Pearse

Research output: Contribution to journalArticlepeer-review


Three pancreatic gastrinomas, associated with the Zollinger-Ellison syndrome, were examined by staining, cytochemical and immunohistochemical, and ultrastructural techniques in order to compare the properties of their storage granules with those of normal gastrin-producing cells. In all three cases, despite their positive anti-gastrin fluorescence, there was only a partial correspondence of properties with those of the pyloric G cell or the pancreatic islet D cell. It is concluded that the available evidence supports the origin of pancreatic gastrinomas from the gastrin-secreting D cell of the normal islet. The relationship of the "small cell" of the normal islet to the D cell on the one hand, and to the gastrinoma cell on the other, has not been determined.

Original languageEnglish
Pages (from-to)66-79
Number of pages14
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Issue number1
Publication statusPublished - Dec 1972

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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