Non-G cell gastrin-producing tumours of the pancreas

G. Vassallo, E. Solcia, G. Bussolati, Julia M. Polak, A. G E Pearse

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Three pancreatic gastrinomas, associated with the Zollinger-Ellison syndrome, were examined by staining, cytochemical and immunohistochemical, and ultrastructural techniques in order to compare the properties of their storage granules with those of normal gastrin-producing cells. In all three cases, despite their positive anti-gastrin fluorescence, there was only a partial correspondence of properties with those of the pyloric G cell or the pancreatic islet D cell. It is concluded that the available evidence supports the origin of pancreatic gastrinomas from the gastrin-secreting D cell of the normal islet. The relationship of the "small cell" of the normal islet to the D cell on the one hand, and to the gastrinoma cell on the other, has not been determined.

Original languageEnglish
Pages (from-to)66-79
Number of pages14
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Volume11
Issue number1
DOIs
Publication statusPublished - Dec 1972

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Gastrinoma
Gastrin-Secreting Cells
Somatostatin-Secreting Cells
Islets of Langerhans
Pancreas
Zollinger-Ellison Syndrome
Gastrins
Fluorescence
Staining and Labeling

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Non-G cell gastrin-producing tumours of the pancreas. / Vassallo, G.; Solcia, E.; Bussolati, G.; Polak, Julia M.; Pearse, A. G E.

In: Virchows Archiv B Cell Pathology Including Molecular Pathology, Vol. 11, No. 1, 12.1972, p. 66-79.

Research output: Contribution to journalArticle

Vassallo, G. ; Solcia, E. ; Bussolati, G. ; Polak, Julia M. ; Pearse, A. G E. / Non-G cell gastrin-producing tumours of the pancreas. In: Virchows Archiv B Cell Pathology Including Molecular Pathology. 1972 ; Vol. 11, No. 1. pp. 66-79.
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