Three pancreatic gastrinomas, associated with the Zollinger-Ellison syndrome, were examined by staining, cytochemical and immunohistochemical, and ultrastructural techniques in order to compare the properties of their storage granules with those of normal gastrin-producing cells. In all three cases, despite their positive anti-gastrin fluorescence, there was only a partial correspondence of properties with those of the pyloric G cell or the pancreatic islet D cell. It is concluded that the available evidence supports the origin of pancreatic gastrinomas from the gastrin-secreting D cell of the normal islet. The relationship of the "small cell" of the normal islet to the D cell on the one hand, and to the gastrinoma cell on the other, has not been determined.
|Number of pages||14|
|Journal||Virchows Archiv B Cell Pathology Including Molecular Pathology|
|Publication status||Published - Dec 1972|
ASJC Scopus subject areas
- Pathology and Forensic Medicine