Non gastro-esophageal reflux disease related esophagitis: an overview with a histologic diagnostic approach

Luca Mastracci, Federica Grillo, Paola Parente, Elettra Unti, Serena Battista, Paola Spaggiari, Michela Campora, Luca Valle, Matteo Fassan, Roberto Fiocca

Research output: Contribution to journalReview articlepeer-review

Abstract

Several pathological conditions, other than gastro-esophageal reflux disease and its complications, can affect the esophagus. While some of these can present with unspecific lesions (i.e. ulcers and epithelial damage) and require clinico-pathological correlation for diagnosis (i.e. drug-induced esophagitis and corrosive esophagitis) other conditions show distinctive histological lesions which enable the pathologist to reach the diagnosis (i.e. some specific infectious esophagites and Crohn's disease). In this context eosinophilic esophagitis is the condition which has been increasingly studied in the last two decades, while lymphocytic esophagitis, a relatively new entity, still represents an enigma. This overview will focus on and describe histologic lesions which allow pathologists to differentiate between these conditions.

Original languageEnglish
Pages (from-to)128-137
Number of pages10
JournalPathologica
Volume112
Issue number3
DOIs
Publication statusPublished - Sep 1 2020

Keywords

  • drug-induced esophagitis
  • eosinophilic esophagitis
  • esophageal Crohn’s disease
  • esophagitis dissecans superficialis
  • lymphocytic esophagitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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