Non-high-density lipoprotein cholesterol (non-HDL-C) levels in children with nonalcoholic fatty liver disease (NAFLD)

Naim Alkhouri, Katharien Eng, Rocio Lopez, Valerio Nobili

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Non-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular disease (CVD) risk in children. Non-high density lipoprotein-cholesterol (non-HDL-C) has been shown to be a good predictor of cardiovascular events. Recent data in adults found non-alcoholic steatohepatitis (NASH) to be associated with significantly higher levels of non-HDL-C than simple steatosis, suggestive it might be used as a non-invasive tool to diagnose NASH. The goal of our study was to assess non-HDL-C levels in children with NAFLD. Our cohort consisted of pediatric patients with biopsy-proven NAFLD. Anthropometric, laboratory, and histologic data were obtained on all patients. Univariable analysis was performed to assess differences in clinical characteristics between groups. Spearman rank correlation coefficients were calculated to assess the correlation between non-HDL-C levels and clinical variables. ANCOVA was used to adjust for possible confounders. 302 subjects with NAFLD were included in our study; 203 with NASH and 99 without NASH. Subjects with NASH had significantly higher non-HDL-C levels than those without (p = 0.004). Histologic features of NASH, including ballooning, inflammation, and fibrosis were found to be weakly correlated with non-HDL-C levels, (p <0.05 for all). After adjusting for the presence of metabolic syndrome (MetS), ALT, and GGT, the association between non-HDL-C and NASH was not significant (p = 0.66). In Conclusion, non-HDL-C levels are higher in children with NASH than those with simple steatosis, suggesting increased CVD risk. This may be a reflection of the higher prevalence of MetS. Non-HDL-C had a positive association with histologic features of NASH.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalSpringerPlus
Volume3
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Fatty Liver
Cardiovascular Diseases
lipoprotein cholesterol
Non-alcoholic Fatty Liver Disease
Nonparametric Statistics
HDL Cholesterol
Fibrosis
Pediatrics
Inflammation
Biopsy

Keywords

  • Atherosclerosis
  • Cardiovascular disease risk
  • Children
  • Histology
  • Non-alcoholic fatty liver disease
  • Non-alcoholic steatohepatitis
  • Non-high-density lipoprotein cholesterol

ASJC Scopus subject areas

  • General

Cite this

Non-high-density lipoprotein cholesterol (non-HDL-C) levels in children with nonalcoholic fatty liver disease (NAFLD). / Alkhouri, Naim; Eng, Katharien; Lopez, Rocio; Nobili, Valerio.

In: SpringerPlus, Vol. 3, No. 1, 2014, p. 1-9.

Research output: Contribution to journalArticle

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