TY - JOUR
T1 - Non-Hodgkin lymphoma among young adults with and without AIDS in Italy
AU - Dal Maso, Luigino
AU - Rezza, Giovanni
AU - Zambon, Paola
AU - Tagliabue, Giovanna
AU - Crocetti, Emanuele
AU - Vercelli, Marina
AU - Zanetti, Roberto
AU - Falcini, Fabio
AU - Tonini, Giuseppe
AU - Mangone, Lucia
AU - De Lisi, Vincenzo
AU - Ferretti, Stefano
AU - Tumino, Rosario
AU - Stanta, Giorgio
AU - Vitarelli, Susanna
AU - Serraino, Diego
AU - Franceschi, Silvia
PY - 2001/8/1
Y1 - 2001/8/1
N2 - To compare the presentation and prognosis of non-Hodgkin lymphoma (NHL) in people with AIDS (PWA) and in the general Italian population, a record linkage study was carried out. The fraction of NHLs attributable to HIV/AIDS was also estimated. Information from the National AIDS Registry (RAIDS) was linked with records from 13 cancer registries (CR), covering about 15% of the Italian population. During the period 1985-94, among PWA ages 15-49, 136 NHLs were identified (8% of all NHLs) and were compared with 1,481 concurrent incident NHL cases of the same age group among non-PWA. Percentages above 13% of all NHLs were registered in the northern areas of Genoa and Varese, i.e., the most heavily affected by the AIDS epidemic. Between 1 year prior to and 3.5 years after AIDS diagnosis, PWA showed an overall standardised incidence ratio (SIR) for NHL of 302. SIR was particularly high (394) within 3 months after AIDS diagnosis and subsequently declined to 170. SIR was somewhat higher in females (428) than in males (280) but similar among intravenous-drug users (299) and other HIV-transmission groups (309). High-grade NHL, particularly immunoblastic and Burkitt's lymphoma, were twice as frequent among PWA than non-PWA. Conversely, low-grade NHL were less frequent. Except for the high proportion of brain localisation, no clear difference emerged in the pattern of NHL presentation site in PWA compared with non-PWA. At variance with NHL in the general population, among PWA histological grade had little impact on survival, which overall appeared to be very poor (2-year survival: 10%; 95% confidence interval: 3%-17%). Our present linkage of RAIDS and CRs represents an efficient tool for the surveillance of trends in incidence and survival of NHL among PWA in Italy.
AB - To compare the presentation and prognosis of non-Hodgkin lymphoma (NHL) in people with AIDS (PWA) and in the general Italian population, a record linkage study was carried out. The fraction of NHLs attributable to HIV/AIDS was also estimated. Information from the National AIDS Registry (RAIDS) was linked with records from 13 cancer registries (CR), covering about 15% of the Italian population. During the period 1985-94, among PWA ages 15-49, 136 NHLs were identified (8% of all NHLs) and were compared with 1,481 concurrent incident NHL cases of the same age group among non-PWA. Percentages above 13% of all NHLs were registered in the northern areas of Genoa and Varese, i.e., the most heavily affected by the AIDS epidemic. Between 1 year prior to and 3.5 years after AIDS diagnosis, PWA showed an overall standardised incidence ratio (SIR) for NHL of 302. SIR was particularly high (394) within 3 months after AIDS diagnosis and subsequently declined to 170. SIR was somewhat higher in females (428) than in males (280) but similar among intravenous-drug users (299) and other HIV-transmission groups (309). High-grade NHL, particularly immunoblastic and Burkitt's lymphoma, were twice as frequent among PWA than non-PWA. Conversely, low-grade NHL were less frequent. Except for the high proportion of brain localisation, no clear difference emerged in the pattern of NHL presentation site in PWA compared with non-PWA. At variance with NHL in the general population, among PWA histological grade had little impact on survival, which overall appeared to be very poor (2-year survival: 10%; 95% confidence interval: 3%-17%). Our present linkage of RAIDS and CRs represents an efficient tool for the surveillance of trends in incidence and survival of NHL among PWA in Italy.
KW - AIDS
KW - Linkage
KW - Non-Hodgkin lymphoma
UR - http://www.scopus.com/inward/record.url?scp=0035427183&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035427183&partnerID=8YFLogxK
U2 - 10.1002/1097-0215(20010801)93:3<430::AID-IJC1344>3.0.CO;2-K
DO - 10.1002/1097-0215(20010801)93:3<430::AID-IJC1344>3.0.CO;2-K
M3 - Article
C2 - 11433410
AN - SCOPUS:0035427183
VL - 93
SP - 430
EP - 435
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 3
ER -