TY - JOUR
T1 - Non-Hodgkin lymphoma and obesity
T2 - A pooled analysis from the InterLymph consortium
AU - Willett, Eleanor V.
AU - Morton, Lindsay M.
AU - Hartge, Patricia
AU - Becker, Nikolaus
AU - Bernstein, Leslie
AU - Boffetta, Paolo
AU - Bracci, Paige
AU - Cerhan, James
AU - Chiu, Brian C H
AU - Cocco, Pierluigi
AU - Dal Maso, Luigino
AU - Davis, Scott
AU - De Sanjose, Silvia
AU - Smedby, Karin Ekstrom
AU - Ennas, Maria Grazia
AU - Foretova, Lenka
AU - Holly, Elizabeth A.
AU - La Vecchia, Carlo
AU - Matsuo, Keitaro
AU - Maynadie, Marc
AU - Melbye, Mads
AU - Negri, Eva
AU - Nieters, Alexandra
AU - Severson, Richard
AU - Slager, Susan L.
AU - Spinelli, John J.
AU - Staines, Anthony
AU - Talamini, Renato
AU - Vornanen, Martine
AU - Weisenburger, Dennis D.
AU - Roman, Eve
PY - 2008/5/1
Y1 - 2008/5/1
N2 - Nutritional status is known to alter immune function, a suspected risk factor for non-Hodgkin lymphoma (NHL). To investigate whether long-term over, or under, nutrition is associated with NHL, self-reported anthropometric data on weight and height from over 10,000 cases of NHL and 16,000 controls were pooled across 18 case-control studies identified through the International Lymphoma Epidemiology Consortium. Study-specific odds ratios (OR) were estimated using logistic regression and combined using a random-effects model. Severe obesity, defined as BMI of 40 kg m-2 or more, was not associated with NHL overall (pooled OR = 1.00, 95% confidence interval (CI) 0.70-1.41) or the majority of NHL subtypes. An excess was however observed for diffuse large B-cell lymphoma (pooled OR = 1.80, 95% CI 1.24-2.62), although not all study-specific ORs were raised. Among the overweight (BMI 25-29.9 kg m -2) and obese (BMI 30-39.9 kg m-2), associations were elevated in some studies and decreased in others, while no association was observed among the underweight (BMI <18.5 kg m-2). There was little suggestion of increasing ORs for NHL or its subtypes with every 5 kg m-2 rise in BMI above 18.5 kg m-2. BMI components height and weight were also examined, and the tallest men, but not women, were at marginally increased risk (pooled OR = 1.19, 95% CI 1.06-1.34). In summary, whilst we conclude that there is no evidence to support the hypothesis that obesity is a determinant of all types of NHL combined, the association between severe obesity and diffuse large B-cell lymphoma may warrant further investigation.
AB - Nutritional status is known to alter immune function, a suspected risk factor for non-Hodgkin lymphoma (NHL). To investigate whether long-term over, or under, nutrition is associated with NHL, self-reported anthropometric data on weight and height from over 10,000 cases of NHL and 16,000 controls were pooled across 18 case-control studies identified through the International Lymphoma Epidemiology Consortium. Study-specific odds ratios (OR) were estimated using logistic regression and combined using a random-effects model. Severe obesity, defined as BMI of 40 kg m-2 or more, was not associated with NHL overall (pooled OR = 1.00, 95% confidence interval (CI) 0.70-1.41) or the majority of NHL subtypes. An excess was however observed for diffuse large B-cell lymphoma (pooled OR = 1.80, 95% CI 1.24-2.62), although not all study-specific ORs were raised. Among the overweight (BMI 25-29.9 kg m -2) and obese (BMI 30-39.9 kg m-2), associations were elevated in some studies and decreased in others, while no association was observed among the underweight (BMI <18.5 kg m-2). There was little suggestion of increasing ORs for NHL or its subtypes with every 5 kg m-2 rise in BMI above 18.5 kg m-2. BMI components height and weight were also examined, and the tallest men, but not women, were at marginally increased risk (pooled OR = 1.19, 95% CI 1.06-1.34). In summary, whilst we conclude that there is no evidence to support the hypothesis that obesity is a determinant of all types of NHL combined, the association between severe obesity and diffuse large B-cell lymphoma may warrant further investigation.
KW - Body mass index
KW - Epidemiology
KW - Height
KW - Lymphoma
KW - Non-Hodgkin lymphoma
KW - Weight
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U2 - 10.1002/ijc.23344
DO - 10.1002/ijc.23344
M3 - Article
C2 - 18167059
AN - SCOPUS:40749120557
VL - 122
SP - 2062
EP - 2070
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 9
ER -