Non-hodgkin lymphomas presenting as soft tissue masses: A single center experience and meta-analysis of the published series

Enrico Derenzini, Beatrice Casadei, Cinzia Pellegrini, Lisa Argnani, Stefano Pileri, Pier Luigi Zinzani

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Lymphomas with involvement of soft tissues as a primary event are very rare. The published studies have a small sample size, most of them being reported as case reports. Patients and Methods: In this article we describe our experience with soft tissue non-Hodgkin lymphomas (NHL) diagnosed and treated in our institution over a 15-year period. Moreover, we systematically review the available data from the literature in the past 2 decades, considering all the published series and case reports available from 1990 to 2011 using a PubMed access. Results: In the monocentric analysis, 16 consecutive patients treated at our Institution from 1996 to 2011 were considered. In the literature search, we selected 16 case reports (18 patients) and 5 case series (49 patients), including a total of 67 patients. Eighty-three patients were finally considered in the combined analysis. The most common histologic subtype was diffuse large B cell lymphoma (DLBCL) (>50% of cases in both groups). In both analyses we observed an inferior outcome for DLBCL compared with indolent B-cell NHL (5-year progression free survival: 34% vs. 64%, respectively, in the combined analysis; P =.01). Furthermore, the prognosis in the DLBCL group appears to be worse compared with the historical data of DLBCL patients treated with chemoimmunotherapy. Conclusions: Though indolent soft tissue B-cell NHLs appear to have a good outcome, soft tissue DLBCLs represent an anatomic-clinical entity with aggressive features, and dismal prognosis. Strategies of first-line therapy intensification could be considered. Studies aiming to a better biologic characterization of this peculiar entity are warranted.

Original languageEnglish
Pages (from-to)258-265
Number of pages8
JournalClinical Lymphoma, Myeloma and Leukemia
Volume13
Issue number3
DOIs
Publication statusPublished - Jun 2013

Fingerprint

Non-Hodgkin's Lymphoma
Meta-Analysis
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
PubMed
Sample Size
Disease-Free Survival
Lymphoma
B-Lymphocytes

Keywords

  • Diffuse large B-cell lymphoma
  • Follicular lymphoma
  • Indolent non-Hodgkin lymphoma
  • Soft tissue lymphoma
  • T-cell lymphoma

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Non-hodgkin lymphomas presenting as soft tissue masses : A single center experience and meta-analysis of the published series. / Derenzini, Enrico; Casadei, Beatrice; Pellegrini, Cinzia; Argnani, Lisa; Pileri, Stefano; Zinzani, Pier Luigi.

In: Clinical Lymphoma, Myeloma and Leukemia, Vol. 13, No. 3, 06.2013, p. 258-265.

Research output: Contribution to journalArticle

Derenzini, Enrico ; Casadei, Beatrice ; Pellegrini, Cinzia ; Argnani, Lisa ; Pileri, Stefano ; Zinzani, Pier Luigi. / Non-hodgkin lymphomas presenting as soft tissue masses : A single center experience and meta-analysis of the published series. In: Clinical Lymphoma, Myeloma and Leukemia. 2013 ; Vol. 13, No. 3. pp. 258-265.
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abstract = "Background: Lymphomas with involvement of soft tissues as a primary event are very rare. The published studies have a small sample size, most of them being reported as case reports. Patients and Methods: In this article we describe our experience with soft tissue non-Hodgkin lymphomas (NHL) diagnosed and treated in our institution over a 15-year period. Moreover, we systematically review the available data from the literature in the past 2 decades, considering all the published series and case reports available from 1990 to 2011 using a PubMed access. Results: In the monocentric analysis, 16 consecutive patients treated at our Institution from 1996 to 2011 were considered. In the literature search, we selected 16 case reports (18 patients) and 5 case series (49 patients), including a total of 67 patients. Eighty-three patients were finally considered in the combined analysis. The most common histologic subtype was diffuse large B cell lymphoma (DLBCL) (>50{\%} of cases in both groups). In both analyses we observed an inferior outcome for DLBCL compared with indolent B-cell NHL (5-year progression free survival: 34{\%} vs. 64{\%}, respectively, in the combined analysis; P =.01). Furthermore, the prognosis in the DLBCL group appears to be worse compared with the historical data of DLBCL patients treated with chemoimmunotherapy. Conclusions: Though indolent soft tissue B-cell NHLs appear to have a good outcome, soft tissue DLBCLs represent an anatomic-clinical entity with aggressive features, and dismal prognosis. Strategies of first-line therapy intensification could be considered. Studies aiming to a better biologic characterization of this peculiar entity are warranted.",
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