Non-immune hydrops fetalis: A short review of etiology and pathophysiology

Carlo Bellini; Raoul Cm Hennekam

doi:10.1002/ajmg.a.34438

Non-immune hydrops fetalis: A short review of etiology and pathophysiology

Carlo Bellini, Raoul Cm Hennekam

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Hydrops fetalis is an excessive accumulation of fetal fluid. Hydrops is traditionally classified into either immune or non-immune hydrops (NIHF), but in practice, nowadays in the Western world >90% of hydrops is of non-immune origin. The basis of the disorder is an imbalance in the regulation of fetal fluid movement between the vascular and interstitial space. We previously suggested a diagnostic flow-chart for NIHF. In this short review we describe the main mechanisms leading to NIHF.

Original language	English
Pages (from-to)	597-605
Number of pages	9
Journal	American Journal of Medical Genetics, Part A
Volume	158 A
Issue number	3
DOIs	https://doi.org/10.1002/ajmg.a.34438
Publication status	Published - Mar 2012

Keywords

Edema of the fetus
Fetal hydrops
NIHF
Non-immune hydrops fetalis
Pathogenesis
Pathophysiologic pathways

ASJC Scopus subject areas

Genetics(clinical)
Genetics

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10.1002/ajmg.a.34438

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Non-immune hydrops fetalis: A short review of etiology and pathophysiology

Abstract

Keywords

ASJC Scopus subject areas

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