Non-intensive care unit acquired pneumonia: A new clinical entity?

Marta Di Pasquale, Stefano Aliberti, Marco Mantero, Sonia Bianchini, Francesco Blasi

Research output: Contribution to journalArticlepeer-review


Hospital-acquired pneumonia (HAP) is a frequent cause of nosocomial infections, responsible for great morbidity and mortality worldwide. The majority of studies on HAP have been conducted in patients hospitalized in the intensive care unit (ICU), as mechanical ventilation represents a major risk factor for nosocomial pneumonia and specifically for ventilator-associated pneumonia. However, epidemiological data seem to be different between patients acquiring HAP in the ICU vs. general wards, suggesting the importance of identifying non ICU-acquired pneumonia (NIAP) as a clinical distinct entity in terms of both etiology and management. Early detection of NIAP, along with an individualized management, is needed to reduce antibiotic use and side effects, bacterial resistance and mortality. The present article reviews the pathophysiology, diagnosis, treatment and prevention of NIAP.

Original languageEnglish
Article number287
JournalInternational Journal of Molecular Sciences
Issue number3
Publication statusPublished - Feb 25 2016


  • Hospital acquired pneumonia
  • Microbiology
  • Nosocomial infection
  • Prevention
  • Risk factors

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications


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