Non-interventional, retrospective data of long-term home parenteral nutrition in patients with benign diseases: Analysis of a nurse register (SERECARE)

Antonella De Francesco, Antonella Diamanti, Paolo Gandullia, Umberto Aimasso, Serena Arrigo, Noemi Brolatti, Teresa Capriati, Domenica Elia, Silvia Mazzuoli, Fabio Dario Merlo, Caterina Pazzeschi, Nunzia Regano, Anna Simona Sasdelli, Loris Pironi, Francesco William Guglielmi

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: The aim of this study was to evaluate the safety and efficacy of home parenteral nutrition (HPN) service in patients with benign chronic intestinal failure (CIF).

METHODS: This was a 10-y retrospective, non-interventional, multicenter study conducted with adult and pediatric patients with CIF who received HPN service. We analyzed data prospectively collected from a dedicated register by HPN nurses.

RESULTS: From January 2002 to December 2011 a total of 794 patients (49.7% male, median age 1 y for children and 57 y for adults) were included in the analysis. Over the 10-y period, 723 central venous catheter (CVC) complications occurred, of which 394 were infectious (54.5%), 297 were mechanical (41.1%), and 32 (3.3%) were defined as CVC-related thrombosis. The complication rate was higher in children (1.11 per patient) than in adults (0.70 per patient). During the observation period, the rates of both infectious and mechanical complications showed a global declining trend and ∼75% of patients had neither infectious nor mechanical CVC complications. HPN efficacy was evaluated in 301 patients with a minimum follow-up of 36 mo. Body mass index and Karnofsky score showed that the median growth significantly increased (P < 0.001) over baseline for adults and pediatric patients in the 0 to 2 age range.

CONCLUSIONS: The use of a structured register has proved to be a key strategy for monitoring the outcomes of long-term treatment, improving time efficiency, and preventing potential malpractice. To our knowledge, this is largest survey ever documented; the results were consistent despite the heterogeneity of the centers because of duly applied standard rules and protocols.

Original languageEnglish
Pages (from-to)131-141
Number of pages11
JournalNutrition
Volume66
DOIs
Publication statusE-pub ahead of print - Mar 7 2019

Fingerprint

Home Parenteral Nutrition
Nurses
Central Venous Catheters
Upper Extremity Deep Vein Thrombosis
Pediatrics
Malpractice
Multicenter Studies
Body Mass Index
Observation
Safety

Cite this

Non-interventional, retrospective data of long-term home parenteral nutrition in patients with benign diseases : Analysis of a nurse register (SERECARE). / De Francesco, Antonella; Diamanti, Antonella; Gandullia, Paolo; Aimasso, Umberto; Arrigo, Serena; Brolatti, Noemi; Capriati, Teresa; Elia, Domenica; Mazzuoli, Silvia; Merlo, Fabio Dario; Pazzeschi, Caterina; Regano, Nunzia; Sasdelli, Anna Simona; Pironi, Loris; Guglielmi, Francesco William.

In: Nutrition, Vol. 66, 07.03.2019, p. 131-141.

Research output: Contribution to journalArticle

De Francesco, A, Diamanti, A, Gandullia, P, Aimasso, U, Arrigo, S, Brolatti, N, Capriati, T, Elia, D, Mazzuoli, S, Merlo, FD, Pazzeschi, C, Regano, N, Sasdelli, AS, Pironi, L & Guglielmi, FW 2019, 'Non-interventional, retrospective data of long-term home parenteral nutrition in patients with benign diseases: Analysis of a nurse register (SERECARE)', Nutrition, vol. 66, pp. 131-141. https://doi.org/10.1016/j.nut.2019.01.006
De Francesco, Antonella ; Diamanti, Antonella ; Gandullia, Paolo ; Aimasso, Umberto ; Arrigo, Serena ; Brolatti, Noemi ; Capriati, Teresa ; Elia, Domenica ; Mazzuoli, Silvia ; Merlo, Fabio Dario ; Pazzeschi, Caterina ; Regano, Nunzia ; Sasdelli, Anna Simona ; Pironi, Loris ; Guglielmi, Francesco William. / Non-interventional, retrospective data of long-term home parenteral nutrition in patients with benign diseases : Analysis of a nurse register (SERECARE). In: Nutrition. 2019 ; Vol. 66. pp. 131-141.
@article{1e7385e946b14a0aa0e724d59a143ca9,
title = "Non-interventional, retrospective data of long-term home parenteral nutrition in patients with benign diseases: Analysis of a nurse register (SERECARE)",
abstract = "OBJECTIVES: The aim of this study was to evaluate the safety and efficacy of home parenteral nutrition (HPN) service in patients with benign chronic intestinal failure (CIF).METHODS: This was a 10-y retrospective, non-interventional, multicenter study conducted with adult and pediatric patients with CIF who received HPN service. We analyzed data prospectively collected from a dedicated register by HPN nurses.RESULTS: From January 2002 to December 2011 a total of 794 patients (49.7{\%} male, median age 1 y for children and 57 y for adults) were included in the analysis. Over the 10-y period, 723 central venous catheter (CVC) complications occurred, of which 394 were infectious (54.5{\%}), 297 were mechanical (41.1{\%}), and 32 (3.3{\%}) were defined as CVC-related thrombosis. The complication rate was higher in children (1.11 per patient) than in adults (0.70 per patient). During the observation period, the rates of both infectious and mechanical complications showed a global declining trend and ∼75{\%} of patients had neither infectious nor mechanical CVC complications. HPN efficacy was evaluated in 301 patients with a minimum follow-up of 36 mo. Body mass index and Karnofsky score showed that the median growth significantly increased (P < 0.001) over baseline for adults and pediatric patients in the 0 to 2 age range.CONCLUSIONS: The use of a structured register has proved to be a key strategy for monitoring the outcomes of long-term treatment, improving time efficiency, and preventing potential malpractice. To our knowledge, this is largest survey ever documented; the results were consistent despite the heterogeneity of the centers because of duly applied standard rules and protocols.",
author = "{De Francesco}, Antonella and Antonella Diamanti and Paolo Gandullia and Umberto Aimasso and Serena Arrigo and Noemi Brolatti and Teresa Capriati and Domenica Elia and Silvia Mazzuoli and Merlo, {Fabio Dario} and Caterina Pazzeschi and Nunzia Regano and Sasdelli, {Anna Simona} and Loris Pironi and Guglielmi, {Francesco William}",
note = "Copyright {\circledC} 2019. Published by Elsevier Inc.",
year = "2019",
month = "3",
day = "7",
doi = "10.1016/j.nut.2019.01.006",
language = "English",
volume = "66",
pages = "131--141",
journal = "Nutrition International",
issn = "0899-9007",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Non-interventional, retrospective data of long-term home parenteral nutrition in patients with benign diseases

T2 - Analysis of a nurse register (SERECARE)

AU - De Francesco, Antonella

AU - Diamanti, Antonella

AU - Gandullia, Paolo

AU - Aimasso, Umberto

AU - Arrigo, Serena

AU - Brolatti, Noemi

AU - Capriati, Teresa

AU - Elia, Domenica

AU - Mazzuoli, Silvia

AU - Merlo, Fabio Dario

AU - Pazzeschi, Caterina

AU - Regano, Nunzia

AU - Sasdelli, Anna Simona

AU - Pironi, Loris

AU - Guglielmi, Francesco William

N1 - Copyright © 2019. Published by Elsevier Inc.

PY - 2019/3/7

Y1 - 2019/3/7

N2 - OBJECTIVES: The aim of this study was to evaluate the safety and efficacy of home parenteral nutrition (HPN) service in patients with benign chronic intestinal failure (CIF).METHODS: This was a 10-y retrospective, non-interventional, multicenter study conducted with adult and pediatric patients with CIF who received HPN service. We analyzed data prospectively collected from a dedicated register by HPN nurses.RESULTS: From January 2002 to December 2011 a total of 794 patients (49.7% male, median age 1 y for children and 57 y for adults) were included in the analysis. Over the 10-y period, 723 central venous catheter (CVC) complications occurred, of which 394 were infectious (54.5%), 297 were mechanical (41.1%), and 32 (3.3%) were defined as CVC-related thrombosis. The complication rate was higher in children (1.11 per patient) than in adults (0.70 per patient). During the observation period, the rates of both infectious and mechanical complications showed a global declining trend and ∼75% of patients had neither infectious nor mechanical CVC complications. HPN efficacy was evaluated in 301 patients with a minimum follow-up of 36 mo. Body mass index and Karnofsky score showed that the median growth significantly increased (P < 0.001) over baseline for adults and pediatric patients in the 0 to 2 age range.CONCLUSIONS: The use of a structured register has proved to be a key strategy for monitoring the outcomes of long-term treatment, improving time efficiency, and preventing potential malpractice. To our knowledge, this is largest survey ever documented; the results were consistent despite the heterogeneity of the centers because of duly applied standard rules and protocols.

AB - OBJECTIVES: The aim of this study was to evaluate the safety and efficacy of home parenteral nutrition (HPN) service in patients with benign chronic intestinal failure (CIF).METHODS: This was a 10-y retrospective, non-interventional, multicenter study conducted with adult and pediatric patients with CIF who received HPN service. We analyzed data prospectively collected from a dedicated register by HPN nurses.RESULTS: From January 2002 to December 2011 a total of 794 patients (49.7% male, median age 1 y for children and 57 y for adults) were included in the analysis. Over the 10-y period, 723 central venous catheter (CVC) complications occurred, of which 394 were infectious (54.5%), 297 were mechanical (41.1%), and 32 (3.3%) were defined as CVC-related thrombosis. The complication rate was higher in children (1.11 per patient) than in adults (0.70 per patient). During the observation period, the rates of both infectious and mechanical complications showed a global declining trend and ∼75% of patients had neither infectious nor mechanical CVC complications. HPN efficacy was evaluated in 301 patients with a minimum follow-up of 36 mo. Body mass index and Karnofsky score showed that the median growth significantly increased (P < 0.001) over baseline for adults and pediatric patients in the 0 to 2 age range.CONCLUSIONS: The use of a structured register has proved to be a key strategy for monitoring the outcomes of long-term treatment, improving time efficiency, and preventing potential malpractice. To our knowledge, this is largest survey ever documented; the results were consistent despite the heterogeneity of the centers because of duly applied standard rules and protocols.

U2 - 10.1016/j.nut.2019.01.006

DO - 10.1016/j.nut.2019.01.006

M3 - Article

C2 - 31276929

VL - 66

SP - 131

EP - 141

JO - Nutrition International

JF - Nutrition International

SN - 0899-9007

ER -