TY - JOUR
T1 - Non-invasive assessment of cardiac hemodynamics in patients with advanced cancer and with chronic heart failure
T2 - A pilot feasibility study
AU - Von Haehling, Stephan
AU - Lainscak, Mitja
AU - Kung, Thomas
AU - Cramer, Larissa
AU - Ful̈ster, Susann
AU - Pelzer, Uwe
AU - Hildebrandt, Bert
AU - Sandek, Anja
AU - Schefold, Joerg C.
AU - Rauchhaus, Mathias
AU - Doehner, Wolfram
AU - Anker, Stefan D.
PY - 2013/4
Y1 - 2013/4
N2 - Introduction: Relationships between cardiac pressure and volume have been suggested as markers of cardiac contractility; parameters include stroke work and the maximal rate of pressure rise during isovolumic contraction (dP/dt max). Patients with cancer often display dyspnea and fatigue. These are also frequent symptoms in patients with chronic heart failure (HF). The reasons for similar symptoms in cancer patients are unknown. Using the novel Nexfin Finapres technique, we sought to assess measures of cardiac performance in patients with cancer and compare these values with those from control subjects and patients with chronic HF. Material and methods: We prospectively studied 98 patients (control n = 18, chronic HF n = 37, advanced pancreatic or colorectal cancer n = 43) and assessed blood pressure (BP), stroke volume (SV), cardiac output (CO), and dP/dtmax at rest. Results: All parameters of interest could be assessed using the Nexfin Finapres technique with SV and CO being significantly higher in patients with cancer than in controls (both p <0.05). The SV was significantly higher in patients with chronic HF than in controls (p <0.05). In patients with cancer, SV correlated with age (r = -0.45, p <0.01) and body weight (r = +0.55, p = 0.0001). In chronic HF, SV declined with increasing age (r = -0.49, p <0.01); in control subjects, SV increased with increasing body weight (r = +0.57, p = 0.01). Conclusions: Patients with cancer tended to display elevated BP, CO, SV, and dP/dt max as compared to control subjects and patients with HF. These findings may reveal an elevated risk for cardiovascular diseases in this group.
AB - Introduction: Relationships between cardiac pressure and volume have been suggested as markers of cardiac contractility; parameters include stroke work and the maximal rate of pressure rise during isovolumic contraction (dP/dt max). Patients with cancer often display dyspnea and fatigue. These are also frequent symptoms in patients with chronic heart failure (HF). The reasons for similar symptoms in cancer patients are unknown. Using the novel Nexfin Finapres technique, we sought to assess measures of cardiac performance in patients with cancer and compare these values with those from control subjects and patients with chronic HF. Material and methods: We prospectively studied 98 patients (control n = 18, chronic HF n = 37, advanced pancreatic or colorectal cancer n = 43) and assessed blood pressure (BP), stroke volume (SV), cardiac output (CO), and dP/dtmax at rest. Results: All parameters of interest could be assessed using the Nexfin Finapres technique with SV and CO being significantly higher in patients with cancer than in controls (both p <0.05). The SV was significantly higher in patients with chronic HF than in controls (p <0.05). In patients with cancer, SV correlated with age (r = -0.45, p <0.01) and body weight (r = +0.55, p = 0.0001). In chronic HF, SV declined with increasing age (r = -0.49, p <0.01); in control subjects, SV increased with increasing body weight (r = +0.57, p = 0.01). Conclusions: Patients with cancer tended to display elevated BP, CO, SV, and dP/dt max as compared to control subjects and patients with HF. These findings may reveal an elevated risk for cardiovascular diseases in this group.
KW - Cancer
KW - Cardiac output
KW - Heart failure
KW - Hemodynamics
KW - Stroke volume
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U2 - 10.5114/aoms.2013.34574
DO - 10.5114/aoms.2013.34574
M3 - Article
C2 - 23671436
AN - SCOPUS:84876933014
VL - 9
SP - 261
EP - 267
JO - Archives of Medical Science
JF - Archives of Medical Science
SN - 1734-1922
IS - 2
ER -