Non invasive assessment of lung disease in ataxia telangiectasia by high-field magnetic resonance imaging

Silvia Montella, Carmine Mollica, Andrea Finocchi, Andrea Pession, Maria Cristina Pietrogrande, Antonino Trizzino, Giusy Ranucci, Marco Maglione, Giuliana Giardino, Marco Salvatore, Francesca Santamaria, Claudio Pignata

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: A sensitive imaging technique that assesses ataxia telangiectasia (AT) lung disease without ionizing radiation is highly desirable. We designed a study to evaluate lung changes using magnetic resonance imaging (MRI), and to investigate the relationships among severity and extent of pulmonary abnormalities and clinical, microbiological and functional data in children and young adults with AT. Methods: Fifteen AT patients (age, 11.3 years; range, 6-31) underwent 3.0-T MRI, spirometry, and deep throat or sputum culture. Images were scored using a modified Helbich score. Results: Although only 8 patients (53 %) had recurrent/chronic respiratory symptoms, MRI identified lung abnormalities in all. Bronchiectasis, peribronchial thickening, mucous plugging, and collapse/consolidation were present in 60 %, 87 %, 67 %, and 13 % of cases, respectively, with no difference between subjects with or without respiratory symptoms. No difference in changes of specific scores was found between the two groups, but the total MRI score was higher in patients with respiratory symptoms (6.5 versus 5, respectively; p = 0.02). Total or specific MRI scores were not associated with patients' age. Of all scores, only mucous plugging subscore appeared significantly related to FEV1 (r = 0.7, p = 0.04) and FEF25-75% (r = 0.9, p = 0.001). MRI scores from patients with positive (n = 5) or negative (n = 10) sputum culture were not significantly different. Conclusions: MRI is valuable in the assessment of extent and severity of pulmonary changes in children and adults with AT. It represents an helpful tool for the longitudinal evaluation of patients and may be also used as an outcome surrogate to track the effects of medications.

Original languageEnglish
Pages (from-to)1185-1191
Number of pages7
JournalJournal of Clinical Immunology
Volume33
Issue number7
DOIs
Publication statusPublished - 2013

Fingerprint

Ataxia Telangiectasia
Lung Diseases
Magnetic Resonance Imaging
Lung
Sputum
Bronchiectasis
Spirometry
Pharynx
Ionizing Radiation
Young Adult

Keywords

  • Ataxia telangiectasia
  • lung disease
  • magnetic resonance imaging
  • pulmonary function

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Non invasive assessment of lung disease in ataxia telangiectasia by high-field magnetic resonance imaging. / Montella, Silvia; Mollica, Carmine; Finocchi, Andrea; Pession, Andrea; Pietrogrande, Maria Cristina; Trizzino, Antonino; Ranucci, Giusy; Maglione, Marco; Giardino, Giuliana; Salvatore, Marco; Santamaria, Francesca; Pignata, Claudio.

In: Journal of Clinical Immunology, Vol. 33, No. 7, 2013, p. 1185-1191.

Research output: Contribution to journalArticle

Montella, S, Mollica, C, Finocchi, A, Pession, A, Pietrogrande, MC, Trizzino, A, Ranucci, G, Maglione, M, Giardino, G, Salvatore, M, Santamaria, F & Pignata, C 2013, 'Non invasive assessment of lung disease in ataxia telangiectasia by high-field magnetic resonance imaging', Journal of Clinical Immunology, vol. 33, no. 7, pp. 1185-1191. https://doi.org/10.1007/s10875-013-9933-y
Montella, Silvia ; Mollica, Carmine ; Finocchi, Andrea ; Pession, Andrea ; Pietrogrande, Maria Cristina ; Trizzino, Antonino ; Ranucci, Giusy ; Maglione, Marco ; Giardino, Giuliana ; Salvatore, Marco ; Santamaria, Francesca ; Pignata, Claudio. / Non invasive assessment of lung disease in ataxia telangiectasia by high-field magnetic resonance imaging. In: Journal of Clinical Immunology. 2013 ; Vol. 33, No. 7. pp. 1185-1191.
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abstract = "Purpose: A sensitive imaging technique that assesses ataxia telangiectasia (AT) lung disease without ionizing radiation is highly desirable. We designed a study to evaluate lung changes using magnetic resonance imaging (MRI), and to investigate the relationships among severity and extent of pulmonary abnormalities and clinical, microbiological and functional data in children and young adults with AT. Methods: Fifteen AT patients (age, 11.3 years; range, 6-31) underwent 3.0-T MRI, spirometry, and deep throat or sputum culture. Images were scored using a modified Helbich score. Results: Although only 8 patients (53 {\%}) had recurrent/chronic respiratory symptoms, MRI identified lung abnormalities in all. Bronchiectasis, peribronchial thickening, mucous plugging, and collapse/consolidation were present in 60 {\%}, 87 {\%}, 67 {\%}, and 13 {\%} of cases, respectively, with no difference between subjects with or without respiratory symptoms. No difference in changes of specific scores was found between the two groups, but the total MRI score was higher in patients with respiratory symptoms (6.5 versus 5, respectively; p = 0.02). Total or specific MRI scores were not associated with patients' age. Of all scores, only mucous plugging subscore appeared significantly related to FEV1 (r = 0.7, p = 0.04) and FEF25-75{\%} (r = 0.9, p = 0.001). MRI scores from patients with positive (n = 5) or negative (n = 10) sputum culture were not significantly different. Conclusions: MRI is valuable in the assessment of extent and severity of pulmonary changes in children and adults with AT. It represents an helpful tool for the longitudinal evaluation of patients and may be also used as an outcome surrogate to track the effects of medications.",
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AU - Montella, Silvia

AU - Mollica, Carmine

AU - Finocchi, Andrea

AU - Pession, Andrea

AU - Pietrogrande, Maria Cristina

AU - Trizzino, Antonino

AU - Ranucci, Giusy

AU - Maglione, Marco

AU - Giardino, Giuliana

AU - Salvatore, Marco

AU - Santamaria, Francesca

AU - Pignata, Claudio

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N2 - Purpose: A sensitive imaging technique that assesses ataxia telangiectasia (AT) lung disease without ionizing radiation is highly desirable. We designed a study to evaluate lung changes using magnetic resonance imaging (MRI), and to investigate the relationships among severity and extent of pulmonary abnormalities and clinical, microbiological and functional data in children and young adults with AT. Methods: Fifteen AT patients (age, 11.3 years; range, 6-31) underwent 3.0-T MRI, spirometry, and deep throat or sputum culture. Images were scored using a modified Helbich score. Results: Although only 8 patients (53 %) had recurrent/chronic respiratory symptoms, MRI identified lung abnormalities in all. Bronchiectasis, peribronchial thickening, mucous plugging, and collapse/consolidation were present in 60 %, 87 %, 67 %, and 13 % of cases, respectively, with no difference between subjects with or without respiratory symptoms. No difference in changes of specific scores was found between the two groups, but the total MRI score was higher in patients with respiratory symptoms (6.5 versus 5, respectively; p = 0.02). Total or specific MRI scores were not associated with patients' age. Of all scores, only mucous plugging subscore appeared significantly related to FEV1 (r = 0.7, p = 0.04) and FEF25-75% (r = 0.9, p = 0.001). MRI scores from patients with positive (n = 5) or negative (n = 10) sputum culture were not significantly different. Conclusions: MRI is valuable in the assessment of extent and severity of pulmonary changes in children and adults with AT. It represents an helpful tool for the longitudinal evaluation of patients and may be also used as an outcome surrogate to track the effects of medications.

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