Non-invasive assessment of vascular function: Paradoxical vascular response to glucose in coronary heart disease

F. Leyva; M. Rauchhaus; A. J. Proudler; S. D. Anker; I. F. Godsland; P. A. Poole-Wilson; A. J. Coats; J. C. Stevenson

Non-invasive assessment of vascular function: Paradoxical vascular response to glucose in coronary heart disease

F. Leyva, M. Rauchhaus, A. J. Proudler, S. D. Anker, I. F. Godsland, P. A. Poole-Wilson, A. J. Coats, J. C. Stevenson

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The vascular effects of insulin are nitric oxide-dependent, and independent of insulin's effect on glucose metabolism. Glucose, administered intravenously (iv.) as in the iv. glucose tolerance test (IVGTT), causes a physiological hyperinsulinaemia. We hypothesised that the this insulin response leads to forearm blood flow (FBF) changes in healthy individuals, and that such a response might be altered in patients with coronary heart disease (CHD). Methods: 10 healthy men and 13 men with angiographically proven CHD [aged 65.5±2.4 yrs, mean±SEM] underwent an IVGTT with simultaneous measurement of FBF (mercury-in-silastic venous occlusion plethysmography) at 28 time points over 3 hrs following iv. glucose administration. Results: In healthy controls, FBF increased to 31.7% above baseline at 7 mins and remained above baseline up to 180 mins after i.v. glucose. Significant group differences emerged in the % change in FBF from baseline at 180 mins (controls: +112.8±24.9%; CHD patients: -25.8±7.3%, p

Original language	English
Journal	Heart
Volume	79
Issue number	SUPPL. 1
Publication status	Published - May 1998

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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title = "Non-invasive assessment of vascular function: Paradoxical vascular response to glucose in coronary heart disease",

abstract = "Background: The vascular effects of insulin are nitric oxide-dependent, and independent of insulin's effect on glucose metabolism. Glucose, administered intravenously (iv.) as in the iv. glucose tolerance test (IVGTT), causes a physiological hyperinsulinaemia. We hypothesised that the this insulin response leads to forearm blood flow (FBF) changes in healthy individuals, and that such a response might be altered in patients with coronary heart disease (CHD). Methods: 10 healthy men and 13 men with angiographically proven CHD [aged 65.5±2.4 yrs, mean±SEM] underwent an IVGTT with simultaneous measurement of FBF (mercury-in-silastic venous occlusion plethysmography) at 28 time points over 3 hrs following iv. glucose administration. Results: In healthy controls, FBF increased to 31.7% above baseline at 7 mins and remained above baseline up to 180 mins after i.v. glucose. Significant group differences emerged in the % change in FBF from baseline at 180 mins (controls: +112.8±24.9%; CHD patients: -25.8±7.3%, p",

author = "F. Leyva and M. Rauchhaus and Proudler, {A. J.} and Anker, {S. D.} and Godsland, {I. F.} and Poole-Wilson, {P. A.} and Coats, {A. J.} and Stevenson, {J. C.}",

year = "1998",

month = may,

language = "English",

volume = "79",

journal = "Heart",

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T1 - Non-invasive assessment of vascular function

T2 - Paradoxical vascular response to glucose in coronary heart disease

AU - Leyva, F.

AU - Rauchhaus, M.

AU - Proudler, A. J.

AU - Anker, S. D.

AU - Godsland, I. F.

AU - Poole-Wilson, P. A.

AU - Coats, A. J.

AU - Stevenson, J. C.

PY - 1998/5

Y1 - 1998/5

N2 - Background: The vascular effects of insulin are nitric oxide-dependent, and independent of insulin's effect on glucose metabolism. Glucose, administered intravenously (iv.) as in the iv. glucose tolerance test (IVGTT), causes a physiological hyperinsulinaemia. We hypothesised that the this insulin response leads to forearm blood flow (FBF) changes in healthy individuals, and that such a response might be altered in patients with coronary heart disease (CHD). Methods: 10 healthy men and 13 men with angiographically proven CHD [aged 65.5±2.4 yrs, mean±SEM] underwent an IVGTT with simultaneous measurement of FBF (mercury-in-silastic venous occlusion plethysmography) at 28 time points over 3 hrs following iv. glucose administration. Results: In healthy controls, FBF increased to 31.7% above baseline at 7 mins and remained above baseline up to 180 mins after i.v. glucose. Significant group differences emerged in the % change in FBF from baseline at 180 mins (controls: +112.8±24.9%; CHD patients: -25.8±7.3%, p

AB - Background: The vascular effects of insulin are nitric oxide-dependent, and independent of insulin's effect on glucose metabolism. Glucose, administered intravenously (iv.) as in the iv. glucose tolerance test (IVGTT), causes a physiological hyperinsulinaemia. We hypothesised that the this insulin response leads to forearm blood flow (FBF) changes in healthy individuals, and that such a response might be altered in patients with coronary heart disease (CHD). Methods: 10 healthy men and 13 men with angiographically proven CHD [aged 65.5±2.4 yrs, mean±SEM] underwent an IVGTT with simultaneous measurement of FBF (mercury-in-silastic venous occlusion plethysmography) at 28 time points over 3 hrs following iv. glucose administration. Results: In healthy controls, FBF increased to 31.7% above baseline at 7 mins and remained above baseline up to 180 mins after i.v. glucose. Significant group differences emerged in the % change in FBF from baseline at 180 mins (controls: +112.8±24.9%; CHD patients: -25.8±7.3%, p

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Non-invasive assessment of vascular function: Paradoxical vascular response to glucose in coronary heart disease

Abstract

ASJC Scopus subject areas

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