Non-invasive cerebellar stimulation in cerebellar disorders

Chiara Di Nuzzo, Fabiana Ruggiero, Francesca Cortese, Ilaria Cova, Alberto Priori, Roberta Ferrucci

Research output: Contribution to journalReview article

Abstract

Background & Objective: Non-invasive brain stimulation (NIBS) might be a valuable therapeutic approach for neurological diseases by modifying the cortical activity in the human brain and promoting neural plasticity. Currently, researchers are exploring the use of NIBS on the cerebellum to promote functional neural changes in cerebellar disorders. In the presence of cerebellar dysfunction, several movement disorders, such as kinetic tremor, ataxia of gait, limb dysmetria and oculomotor deficits, become progressively more disabling in daily life, and no pharmacological treatments currently exist. Conclusion: In the present mini-review, we report the main evidence concerning the use of NIBS in three specific cerebellar dysfunctions, cerebellar ataxias (CA), essential tremor (ET) and ataxic cerebral palsy, in which abnormalities of neuroplasticity and cortical excitability can be important pathophysiological factors.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalCNS and Neurological Disorders - Drug Targets
Volume17
Issue number3
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Cerebellar ataxia
  • Children ataxic cerebral palsy
  • Clinical treatment
  • Essential tremor
  • Neuromodulation
  • Non-invasive cerebellar stimulation
  • Noninvasive brain stimulation
  • TACS
  • TDCS
  • TMS

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

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