Non-invasive ventilation in amyotrophic lateral sclerosis: A 10 year population based study

Adriano Chiò, Andrea Calvo, Cristina Moglia, Federica Gamna, Alessio Mattei, Letizia Mazzini, Gabriele Mora, S. Cammarosano, A. Canosa, S. Gallo, D. Cocito, R. Mutani, L. Durelli, B. Ferrero, A. Bertolotto, A. Mauro, M. Leone, F. Monaco, N. Nasuelli, D. GiobbeL. Sosso, M. Gionco, D. Leotta, L. Appendino, D. Imperiale, R. Cavallo, E. Oddenino, C. Geda, F. Poglio, C. Doriguzzi Bozzo, P. Santimaria, U. Massazza, A. Villani, R. Conti, F. Pisano, M. Palermo, E. Ursino, F. Vergnano, O. Sassone, P. Provera, M. T. Penza, M. Aguggia, N. Di Vito, P. Meineri, I. Pastore, P. Ghiglione, D. Seliak, C. Cavestro, G. Astegiano, G. Corso, E. Bottacchi

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate the clinical characteristics and outcome of non-invasive ventilation (NIV) in an epidemiological based series of amyotrophic lateral sclerosis (ALS) patients. Methods: The study was performed using data from the Piemonte and Valle d'Aosta Register for ALS, a prospective epidemiological register enrolling all ALS incident cases in two Italian regions. Results: Among the 1260 patients incident in the period 1995-2004, 259 (20.6%) underwent NIV. Young male patients and subjects attending the tertiary ALS centres were more likely to undergo NIV. There was a progressive significant increase in the use of NIV during the study but was limited to patients attending the ALS tertiary centres. Median survival after NIV was 289 days (95% CI 255 to 333). Conclusions: In an epidemiological setting, NIV represents an increasingly utilised option for the treatment of respiratory disturbances in ALS and has favourable effects on survival, in particular among patients followed by tertiary ALS centres. Sociocultural factors, such as age, gender and marital status, strongly influence the probability of undergoing NIV. Efforts should be made to remove these obstacles in order to spread the use of NIV in all ALS patients with respiratory failure.

Original languageEnglish
Pages (from-to)377-381
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number4
Publication statusPublished - Apr 2012

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Arts and Humanities (miscellaneous)


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