Non-linear regularity of arterial blood pressure variability in patient with atrial fibrillation in tilt-test procedure

Sergio Cerutti, Valentina D A Corino, LucaT Mainardi, Federico Lombardi, Md Aktaruzzaman, Roberto Sassi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

AIMS: Dynamics of cardiovascular series may be explored with non-linear techniques. It is unknown if the arterial pressure irregularity commonly observed in patients with atrial fibrillation (AF) might be further increased by a sympathetic stimulus such as orthostatic tilt.

METHODS AND RESULTS: Twenty patients (62 ± 14 years, 15 men) were recruited for the study. Continuous beat-to-beat non-invasive arterial pressure was acquired at rest and during a passive orthostatic stimulus ('tilt test'). Systolic (SAP) and diastolic (DAP) arterial pressure series of 300 samples were analysed in both conditions. Approximate (ApEn) and sample entropy (SampEn) were computed, as irregularity measures. Equivalent metrics (ApEnAR and SampEnAR) derived from an autoregressive model of the series were also obtained through numerical simulations, to further elucidate the non-linear mechanisms present in the series. In 11 patients (Group A), SAP significantly increased during tilt (from 103 ± 13 to 114 ± 17 mmHg, P <0.001 rest vs. tilt), whereas in 9 patients (Group B) SAP remained almost unchanged (SAP: 110 ± 18 vs. 106 ± 19 mmHg, rest vs. tilt). No clinical differences were found between Groups A and B. When analysing Group A, all irregularity measures significantly increased in SAP (ApEn: 1.75 ± 0.20 vs. 1.88 ± 0.16, P <0.05; SampEn: 1.71 ± 0.30 vs. 1.88 ± 0.27, P <0.05; ApEnAR: 1.87 ± 0.20 vs. 1.96 ± 0.18, P <0.05; SampEnAR: 1.94 ± 0.27 vs. 2.06 ± 0.18, P <0.05; rest vs. tilt), whereas no differences were found in DAP series. No significant differences were found in Group B for either SAP or DAP.

CONCLUSION: The alterations of SAP during tilt in AF patients are not uniform and seem associated with different regularity patterns. The pressor response to sympathetic stimulation was also associated with an increase of SAP series irregularity.

Original languageEnglish
Pages (from-to)iv141-iv147
JournalEuropace
Volume16
DOIs
Publication statusPublished - Nov 1 2014

Fingerprint

Atrial Fibrillation
Arterial Pressure
Entropy

Keywords

  • AF
  • Blood pressure
  • Non-linear analysis
  • Study
  • Tilt test

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Non-linear regularity of arterial blood pressure variability in patient with atrial fibrillation in tilt-test procedure. / Cerutti, Sergio; Corino, Valentina D A; Mainardi, LucaT; Lombardi, Federico; Aktaruzzaman, Md; Sassi, Roberto.

In: Europace, Vol. 16, 01.11.2014, p. iv141-iv147.

Research output: Contribution to journalArticle

Cerutti, Sergio ; Corino, Valentina D A ; Mainardi, LucaT ; Lombardi, Federico ; Aktaruzzaman, Md ; Sassi, Roberto. / Non-linear regularity of arterial blood pressure variability in patient with atrial fibrillation in tilt-test procedure. In: Europace. 2014 ; Vol. 16. pp. iv141-iv147.
@article{ae3dae6e211841e584fd1418ff7de763,
title = "Non-linear regularity of arterial blood pressure variability in patient with atrial fibrillation in tilt-test procedure",
abstract = "AIMS: Dynamics of cardiovascular series may be explored with non-linear techniques. It is unknown if the arterial pressure irregularity commonly observed in patients with atrial fibrillation (AF) might be further increased by a sympathetic stimulus such as orthostatic tilt.METHODS AND RESULTS: Twenty patients (62 ± 14 years, 15 men) were recruited for the study. Continuous beat-to-beat non-invasive arterial pressure was acquired at rest and during a passive orthostatic stimulus ('tilt test'). Systolic (SAP) and diastolic (DAP) arterial pressure series of 300 samples were analysed in both conditions. Approximate (ApEn) and sample entropy (SampEn) were computed, as irregularity measures. Equivalent metrics (ApEnAR and SampEnAR) derived from an autoregressive model of the series were also obtained through numerical simulations, to further elucidate the non-linear mechanisms present in the series. In 11 patients (Group A), SAP significantly increased during tilt (from 103 ± 13 to 114 ± 17 mmHg, P <0.001 rest vs. tilt), whereas in 9 patients (Group B) SAP remained almost unchanged (SAP: 110 ± 18 vs. 106 ± 19 mmHg, rest vs. tilt). No clinical differences were found between Groups A and B. When analysing Group A, all irregularity measures significantly increased in SAP (ApEn: 1.75 ± 0.20 vs. 1.88 ± 0.16, P <0.05; SampEn: 1.71 ± 0.30 vs. 1.88 ± 0.27, P <0.05; ApEnAR: 1.87 ± 0.20 vs. 1.96 ± 0.18, P <0.05; SampEnAR: 1.94 ± 0.27 vs. 2.06 ± 0.18, P <0.05; rest vs. tilt), whereas no differences were found in DAP series. No significant differences were found in Group B for either SAP or DAP.CONCLUSION: The alterations of SAP during tilt in AF patients are not uniform and seem associated with different regularity patterns. The pressor response to sympathetic stimulation was also associated with an increase of SAP series irregularity.",
keywords = "AF, Blood pressure, Non-linear analysis, Study, Tilt test",
author = "Sergio Cerutti and Corino, {Valentina D A} and LucaT Mainardi and Federico Lombardi and Md Aktaruzzaman and Roberto Sassi",
year = "2014",
month = "11",
day = "1",
doi = "10.1093/europace/euu262",
language = "English",
volume = "16",
pages = "iv141--iv147",
journal = "Europace",
issn = "1099-5129",
publisher = "Oxford University Press",

}

TY - JOUR

T1 - Non-linear regularity of arterial blood pressure variability in patient with atrial fibrillation in tilt-test procedure

AU - Cerutti, Sergio

AU - Corino, Valentina D A

AU - Mainardi, LucaT

AU - Lombardi, Federico

AU - Aktaruzzaman, Md

AU - Sassi, Roberto

PY - 2014/11/1

Y1 - 2014/11/1

N2 - AIMS: Dynamics of cardiovascular series may be explored with non-linear techniques. It is unknown if the arterial pressure irregularity commonly observed in patients with atrial fibrillation (AF) might be further increased by a sympathetic stimulus such as orthostatic tilt.METHODS AND RESULTS: Twenty patients (62 ± 14 years, 15 men) were recruited for the study. Continuous beat-to-beat non-invasive arterial pressure was acquired at rest and during a passive orthostatic stimulus ('tilt test'). Systolic (SAP) and diastolic (DAP) arterial pressure series of 300 samples were analysed in both conditions. Approximate (ApEn) and sample entropy (SampEn) were computed, as irregularity measures. Equivalent metrics (ApEnAR and SampEnAR) derived from an autoregressive model of the series were also obtained through numerical simulations, to further elucidate the non-linear mechanisms present in the series. In 11 patients (Group A), SAP significantly increased during tilt (from 103 ± 13 to 114 ± 17 mmHg, P <0.001 rest vs. tilt), whereas in 9 patients (Group B) SAP remained almost unchanged (SAP: 110 ± 18 vs. 106 ± 19 mmHg, rest vs. tilt). No clinical differences were found between Groups A and B. When analysing Group A, all irregularity measures significantly increased in SAP (ApEn: 1.75 ± 0.20 vs. 1.88 ± 0.16, P <0.05; SampEn: 1.71 ± 0.30 vs. 1.88 ± 0.27, P <0.05; ApEnAR: 1.87 ± 0.20 vs. 1.96 ± 0.18, P <0.05; SampEnAR: 1.94 ± 0.27 vs. 2.06 ± 0.18, P <0.05; rest vs. tilt), whereas no differences were found in DAP series. No significant differences were found in Group B for either SAP or DAP.CONCLUSION: The alterations of SAP during tilt in AF patients are not uniform and seem associated with different regularity patterns. The pressor response to sympathetic stimulation was also associated with an increase of SAP series irregularity.

AB - AIMS: Dynamics of cardiovascular series may be explored with non-linear techniques. It is unknown if the arterial pressure irregularity commonly observed in patients with atrial fibrillation (AF) might be further increased by a sympathetic stimulus such as orthostatic tilt.METHODS AND RESULTS: Twenty patients (62 ± 14 years, 15 men) were recruited for the study. Continuous beat-to-beat non-invasive arterial pressure was acquired at rest and during a passive orthostatic stimulus ('tilt test'). Systolic (SAP) and diastolic (DAP) arterial pressure series of 300 samples were analysed in both conditions. Approximate (ApEn) and sample entropy (SampEn) were computed, as irregularity measures. Equivalent metrics (ApEnAR and SampEnAR) derived from an autoregressive model of the series were also obtained through numerical simulations, to further elucidate the non-linear mechanisms present in the series. In 11 patients (Group A), SAP significantly increased during tilt (from 103 ± 13 to 114 ± 17 mmHg, P <0.001 rest vs. tilt), whereas in 9 patients (Group B) SAP remained almost unchanged (SAP: 110 ± 18 vs. 106 ± 19 mmHg, rest vs. tilt). No clinical differences were found between Groups A and B. When analysing Group A, all irregularity measures significantly increased in SAP (ApEn: 1.75 ± 0.20 vs. 1.88 ± 0.16, P <0.05; SampEn: 1.71 ± 0.30 vs. 1.88 ± 0.27, P <0.05; ApEnAR: 1.87 ± 0.20 vs. 1.96 ± 0.18, P <0.05; SampEnAR: 1.94 ± 0.27 vs. 2.06 ± 0.18, P <0.05; rest vs. tilt), whereas no differences were found in DAP series. No significant differences were found in Group B for either SAP or DAP.CONCLUSION: The alterations of SAP during tilt in AF patients are not uniform and seem associated with different regularity patterns. The pressor response to sympathetic stimulation was also associated with an increase of SAP series irregularity.

KW - AF

KW - Blood pressure

KW - Non-linear analysis

KW - Study

KW - Tilt test

UR - http://www.scopus.com/inward/record.url?scp=84934280066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84934280066&partnerID=8YFLogxK

U2 - 10.1093/europace/euu262

DO - 10.1093/europace/euu262

M3 - Article

C2 - 25362165

AN - SCOPUS:84934280066

VL - 16

SP - iv141-iv147

JO - Europace

JF - Europace

SN - 1099-5129

ER -