Non-lipid-related effects of statins

Stefano Bellosta, Nicola Ferri, Franco Bernini, Rodolfo Paoletti, Alberto Corsini

Research output: Contribution to journalArticle

Abstract

The beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) on coronary events have generally been attributed to their hypocholesterolaemic properties. However, as mevalonate and other intermediates of cholesterol synthesis (isoprenoids) are necessary for cell proliferation and other important cell functions, effects other than cholesterol reduction may explain the pharmacological properties of statins. In the present review, we discuss the current knowledge on the nonlipid-related effects of statins, with a special emphasis on their potential benefits in different diseases, such as atherosclerosis and cancer. The mechanism(s) responsible for their favourable properties are also reviewed.

Original languageEnglish
Pages (from-to)164-176
Number of pages13
JournalAnnals of Medicine
Volume32
Issue number3
Publication statusPublished - Apr 2000

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Keywords

  • Arterial smooth muscle cell proliferation
  • Atherosclerosis
  • Cancer
  • Cholesterol accumulation
  • Endothelial function
  • Inflammation
  • Macrophages
  • Migration
  • Statins
  • Thrombosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bellosta, S., Ferri, N., Bernini, F., Paoletti, R., & Corsini, A. (2000). Non-lipid-related effects of statins. Annals of Medicine, 32(3), 164-176.