OSTEOSARCOMA NON METASTATICO DELLE ESTREMITA: PATTERN DI RICADUTA IN FUNZIONE DEL TIPO DI TRATTAMENTO E MODULAZIONE DEL FOLLOW-UP RADIOLOGICO DEL TORACE

Translated title of the contribution: Non-metastatic osteosarcoma of the extremities: Different patterns of recurrence according to the treatment and timing of the radiological follow-up of the chest

E. Rimondi, S. Ferrari, A. Briccoli, D. Iantorno, C. Forni, G. Bacci

Research output: Contribution to journalArticle

Abstract

The authors analysed the patterns of recurrence of osteosarcoma of the extremities treated between 1959 and 1989 either with surgery alone (1959-71) or with combined surgery and adjuvant (1972-82) or neoadjuvant chemotherapy (1983-89). In a total of 452 patients with recurrent osteosarcoma, the initial site of metastasis was the lung in 88% of cases independently of the type of treatment received. The mean period of onset of pulmonary metastasis differed according to the type of treatment performed: 8 months for patients treated with surgery alone; 15.9 months for those treated with adjuvant chemotherapy and 20.3 months for patients treated with neoadjuvant chemotherapy. The incidence of metastases appearing within 12 months of FU was 87%, 56% and 21% respectively. In a most recent and effective neoadjuvant protocol (66% DFS), the incidence of recurrence owing to pulmonary metastasis during the first year of FU was 2% and as much as 75% of all recurrences were concentrated in the following 18 months. Surgery for pulmonary metastasis in patients undergoing chemotherapy was performed in 54 cases with secondary healing in 14 (26%). On the basis of these results the authors suggest a scheme of radiological follow-up for patients with osteosarcoma of the extremities treated with neoadjuvant chemotherapy with intensified controls (every 2 months) during the period with the highest risk of recurrence (13-20 months) and four-monthly controls during the first year and after 31 months of FU. In order to increase the efficacy of FU controls during the high-risk period, the a. propose using CT controls instead of chest X-rays at months 14, 20 and 26.

Original languageItalian
Pages (from-to)9-15
Number of pages7
JournalMinerva Medica
Volume87
Issue number1-2
Publication statusPublished - Jan 1996

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Osteosarcoma
Thorax
Extremities
Neoplasm Metastasis
Recurrence
Drug Therapy
Lung
Therapeutics
Incidence
Adjuvant Chemotherapy
X-Rays

ASJC Scopus subject areas

  • Medicine(all)

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OSTEOSARCOMA NON METASTATICO DELLE ESTREMITA : PATTERN DI RICADUTA IN FUNZIONE DEL TIPO DI TRATTAMENTO E MODULAZIONE DEL FOLLOW-UP RADIOLOGICO DEL TORACE. / Rimondi, E.; Ferrari, S.; Briccoli, A.; Iantorno, D.; Forni, C.; Bacci, G.

In: Minerva Medica, Vol. 87, No. 1-2, 01.1996, p. 9-15.

Research output: Contribution to journalArticle

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abstract = "The authors analysed the patterns of recurrence of osteosarcoma of the extremities treated between 1959 and 1989 either with surgery alone (1959-71) or with combined surgery and adjuvant (1972-82) or neoadjuvant chemotherapy (1983-89). In a total of 452 patients with recurrent osteosarcoma, the initial site of metastasis was the lung in 88{\%} of cases independently of the type of treatment received. The mean period of onset of pulmonary metastasis differed according to the type of treatment performed: 8 months for patients treated with surgery alone; 15.9 months for those treated with adjuvant chemotherapy and 20.3 months for patients treated with neoadjuvant chemotherapy. The incidence of metastases appearing within 12 months of FU was 87{\%}, 56{\%} and 21{\%} respectively. In a most recent and effective neoadjuvant protocol (66{\%} DFS), the incidence of recurrence owing to pulmonary metastasis during the first year of FU was 2{\%} and as much as 75{\%} of all recurrences were concentrated in the following 18 months. Surgery for pulmonary metastasis in patients undergoing chemotherapy was performed in 54 cases with secondary healing in 14 (26{\%}). On the basis of these results the authors suggest a scheme of radiological follow-up for patients with osteosarcoma of the extremities treated with neoadjuvant chemotherapy with intensified controls (every 2 months) during the period with the highest risk of recurrence (13-20 months) and four-monthly controls during the first year and after 31 months of FU. In order to increase the efficacy of FU controls during the high-risk period, the a. propose using CT controls instead of chest X-rays at months 14, 20 and 26.",
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