Non-occupational risk factors for adult soft-tissue sarcoma in northern Italy

Diego Serraino, Silvia Franceschi, Renato Talamini, Sergio Frustaci, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review


The role of socioeconomic and anthropometric indicators, tobacco, alcohol consumption, dietary habits, and medical history in the etiology of soft-tissue sarcoma (STS) was examined in a hospital-based case-control study, conducted in the Friuli-Venezia Giulia region of northeast Italy, between 1985 and 1990. A total of 88 STS cases (53 males and 35 females; median age: 52 years) and of 610 controls (306 males and 304 females; median age: 54 years) were interviewed. There were significant excess risks associated with a history of herpes zoster infection (odds ratio [OR]=2.4,95 percent confidence interval [CI]=1.1-5.3), chicken pox (OR=2.2, CI=1.2-4.3) and mumps in childhood (OR=2.0, CI=1.1-3.9). History of diabetes was also linked to a nonsignificant increase in STS risk (OR=1.8, CI=0.6-5.4), whereas exposure to radiation for diagnostic or therapeutic purposes was not related to the probability of developing STS. None of the investigated socioeconomic and anthropometric indicators seemed to affect STS risk; neither did tobacco smoking, nor consumption of alcohol, coffee, and tea beverages. Conversely, among the dietary habits investigated, a significant positive association emerged with an increasing frequency of consumption of dairy products ({Mathematical expression} or trend=6.8, P

Original languageEnglish
Pages (from-to)157-164
Number of pages8
JournalCancer Causes and Control
Issue number3
Publication statusPublished - May 1991


  • Alcohol
  • case-control study
  • diet
  • Italy
  • medical history
  • smoking
  • soft-tissue sarcoma

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research


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