Non-pegylated liposomal doxorubicin (Myocet®) in patients with poor-risk aggressive B-cell non-Hodgkin lymphoma

Matteo Dell'Olio, Rosario Potito Scalzulli, Grazia Sanpaolo, Michele Nobile, Francesco Saverio Mantuano, Antonio La Sala, Giovanni D'Arena, Eustachio Miraglia, Anna Lucania, Lucia Mastrullo, Cascavilla Nicola

Research output: Contribution to journalArticle

Abstract

The incidence of non-Hodgkin lymphomas increases with age. Non-pegylated liposomal formulations of doxorubicin (Myocet®) reduce systemic and cardiac toxicity especially in the elderly, who often have cardiac diseases. We treated 80 patients (mean age 70.9 years) with poor-risk diffuse large B-cell lymphoma with the R-COMP 21 regimen (Myocet® 50 mg/m2, cyclophosphamide 750 mg/m2, vincristine 1.4 mg/m2, rituximab 375 mg/m 2, prednisone 100 mg/day). In all, 82.5% and 13.7% patients showed complete and partial responses, respectively. Sixty-two of the 80 patients are alive and disease-free (77.5%), while 3/80 are alive with active disease and 15 patients (18.7%) have died (median follow-up: 31 months). The estimated probability of overall survival at 12/24 months from admission was 93.5/87.3%, respectively. There were no therapy-related cardiac events and the ejection fraction improved (from 51.6±6.9% to 54.2±3.9%). Grade 3-4 neutropenia occurred in 22% of patients. We concluded that Myocet® shows both efficacy and tolerability, mainly at the cardiac level.

Original languageEnglish
Pages (from-to)1222-1229
Number of pages8
JournalLeukemia and Lymphoma
Volume52
Issue number7
DOIs
Publication statusPublished - Jul 2011

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Keywords

  • B-cell lymphoma
  • cardiac toxicity
  • non-pegylated liposomal doxorubicin
  • poor-risk patients

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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