Non -pharmacological approaches for headaches in young age: An updated review

Frank Andrasik, Licia Grazzi, Emanuela Sansone, Domenico D'Amico, Alberto Raggi, Eleonora Grignani

Research output: Contribution to journalReview article

Abstract

Headache disorders are common in children and adolescents. Most of the studies on non-pharmacological treatments have however been carried out on adults. In this review we provide information on recent studies examining non-pharmacological approaches for managing headache in children and adolescents. Our search of SCOPUS for primary studies conducted between January 2010 and July 2018 uncovered 11 controlled studies, mostly addressing behavioral approaches, in which a total of 613 patients with a diagnosis of primary headache, and average age 10.2-15.7 years (30-89% females) were recruited. Non-pharmacological treatments were shown to produce sizeable effects on the classical primary endpoint, i.e., headache frequency, with reductions from baseline ranging between 34 and 78%. Among commonly reported secondary endpoints, particularly disability, quality of life, depression and anxiety, marked improvements were noted as well. Taken as a whole, our findings suggest that non-pharmacological treatments constitute a valid option for the prevention of primary headaches in young age. Future research with higher-quality studies is needed. Particular attention needs to be given to studies that randomize patients to condition, blind researchers in charge of evaluating treatment outcomes, routinely include headache frequency as the primary endpoint, include adequate-length follow-up, address changes in biomarkers of disease and other possible mediators of outcome, and that employ predictive models to enhance the level of evidence for these approaches.

Original languageEnglish
Article number01009
JournalFrontiers in Neurology
Volume9
Issue numberNOV
DOIs
Publication statusPublished - Nov 27 2018

Fingerprint

Headache
Pharmacology
Headache Disorders
Primary Prevention
Therapeutics
Anxiety
Biomarkers
Quality of Life
Research Personnel
Depression

Keywords

  • Biofeedback
  • Cognitive-behavioral therapy
  • Depression
  • Disability
  • Migraine
  • Mindfulness
  • Tension-type headache
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Non -pharmacological approaches for headaches in young age : An updated review. / Andrasik, Frank; Grazzi, Licia; Sansone, Emanuela; D'Amico, Domenico; Raggi, Alberto; Grignani, Eleonora.

In: Frontiers in Neurology, Vol. 9, No. NOV, 01009, 27.11.2018.

Research output: Contribution to journalReview article

@article{8db446c6dc6f447097da0ad82f201a4c,
title = "Non -pharmacological approaches for headaches in young age: An updated review",
abstract = "Headache disorders are common in children and adolescents. Most of the studies on non-pharmacological treatments have however been carried out on adults. In this review we provide information on recent studies examining non-pharmacological approaches for managing headache in children and adolescents. Our search of SCOPUS for primary studies conducted between January 2010 and July 2018 uncovered 11 controlled studies, mostly addressing behavioral approaches, in which a total of 613 patients with a diagnosis of primary headache, and average age 10.2-15.7 years (30-89{\%} females) were recruited. Non-pharmacological treatments were shown to produce sizeable effects on the classical primary endpoint, i.e., headache frequency, with reductions from baseline ranging between 34 and 78{\%}. Among commonly reported secondary endpoints, particularly disability, quality of life, depression and anxiety, marked improvements were noted as well. Taken as a whole, our findings suggest that non-pharmacological treatments constitute a valid option for the prevention of primary headaches in young age. Future research with higher-quality studies is needed. Particular attention needs to be given to studies that randomize patients to condition, blind researchers in charge of evaluating treatment outcomes, routinely include headache frequency as the primary endpoint, include adequate-length follow-up, address changes in biomarkers of disease and other possible mediators of outcome, and that employ predictive models to enhance the level of evidence for these approaches.",
keywords = "Biofeedback, Cognitive-behavioral therapy, Depression, Disability, Migraine, Mindfulness, Tension-type headache, Transcranial magnetic stimulation",
author = "Frank Andrasik and Licia Grazzi and Emanuela Sansone and Domenico D'Amico and Alberto Raggi and Eleonora Grignani",
year = "2018",
month = "11",
day = "27",
doi = "10.3389/fneur.2018.01009",
language = "English",
volume = "9",
journal = "Frontiers in Neurology",
issn = "1664-2295",
publisher = "Frontiers Research Foundation",
number = "NOV",

}

TY - JOUR

T1 - Non -pharmacological approaches for headaches in young age

T2 - An updated review

AU - Andrasik, Frank

AU - Grazzi, Licia

AU - Sansone, Emanuela

AU - D'Amico, Domenico

AU - Raggi, Alberto

AU - Grignani, Eleonora

PY - 2018/11/27

Y1 - 2018/11/27

N2 - Headache disorders are common in children and adolescents. Most of the studies on non-pharmacological treatments have however been carried out on adults. In this review we provide information on recent studies examining non-pharmacological approaches for managing headache in children and adolescents. Our search of SCOPUS for primary studies conducted between January 2010 and July 2018 uncovered 11 controlled studies, mostly addressing behavioral approaches, in which a total of 613 patients with a diagnosis of primary headache, and average age 10.2-15.7 years (30-89% females) were recruited. Non-pharmacological treatments were shown to produce sizeable effects on the classical primary endpoint, i.e., headache frequency, with reductions from baseline ranging between 34 and 78%. Among commonly reported secondary endpoints, particularly disability, quality of life, depression and anxiety, marked improvements were noted as well. Taken as a whole, our findings suggest that non-pharmacological treatments constitute a valid option for the prevention of primary headaches in young age. Future research with higher-quality studies is needed. Particular attention needs to be given to studies that randomize patients to condition, blind researchers in charge of evaluating treatment outcomes, routinely include headache frequency as the primary endpoint, include adequate-length follow-up, address changes in biomarkers of disease and other possible mediators of outcome, and that employ predictive models to enhance the level of evidence for these approaches.

AB - Headache disorders are common in children and adolescents. Most of the studies on non-pharmacological treatments have however been carried out on adults. In this review we provide information on recent studies examining non-pharmacological approaches for managing headache in children and adolescents. Our search of SCOPUS for primary studies conducted between January 2010 and July 2018 uncovered 11 controlled studies, mostly addressing behavioral approaches, in which a total of 613 patients with a diagnosis of primary headache, and average age 10.2-15.7 years (30-89% females) were recruited. Non-pharmacological treatments were shown to produce sizeable effects on the classical primary endpoint, i.e., headache frequency, with reductions from baseline ranging between 34 and 78%. Among commonly reported secondary endpoints, particularly disability, quality of life, depression and anxiety, marked improvements were noted as well. Taken as a whole, our findings suggest that non-pharmacological treatments constitute a valid option for the prevention of primary headaches in young age. Future research with higher-quality studies is needed. Particular attention needs to be given to studies that randomize patients to condition, blind researchers in charge of evaluating treatment outcomes, routinely include headache frequency as the primary endpoint, include adequate-length follow-up, address changes in biomarkers of disease and other possible mediators of outcome, and that employ predictive models to enhance the level of evidence for these approaches.

KW - Biofeedback

KW - Cognitive-behavioral therapy

KW - Depression

KW - Disability

KW - Migraine

KW - Mindfulness

KW - Tension-type headache

KW - Transcranial magnetic stimulation

UR - http://www.scopus.com/inward/record.url?scp=85057818782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057818782&partnerID=8YFLogxK

U2 - 10.3389/fneur.2018.01009

DO - 10.3389/fneur.2018.01009

M3 - Review article

AN - SCOPUS:85057818782

VL - 9

JO - Frontiers in Neurology

JF - Frontiers in Neurology

SN - 1664-2295

IS - NOV

M1 - 01009

ER -