Non-progressive leukoencephalopathy with bilateral anterior temporal cysts: A case report and review of the literature

Salvatore Grosso, Alfonso Cerase, Nicola De Stefano, Luisa D. Marco, Paolo Galluzzi, Daniela Galimberti, Guido Morgese, Paolo Balestri

Research output: Contribution to journalArticle

Abstract

A newly described disease is characterized by anterior bilateral temporal lobe cysts associated with multilobar leukoencephalopathy and a non-progressive clinical course. We report a patient with bilateral anterior temporal lobe cystic changes associated with a non-progressive neurological disorder, microcephaly, spasticity, mental retardation, and sensorineural deafness. From the literature, 12 other patients have shown a similar phenotype. The common neuroradiological findings in these patients have been bilateral anterior temporal lobe cystic changes and non-progressive leukoencephalopathy. By contrast, variability in the clinical phenotype has been observed, ranging from severe neuromotor handicap with mental retardation and microcephaly to spasticity in the lower limbs associated with normal cognitive function. The pathological basis of the defect remains to be defined.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalBrain and Development
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 2005

Keywords

  • Leukoencephalopathy
  • Mental retardation
  • Spasticity
  • Temporal lobe cysts

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

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