Non isotopic in situ hybridization with alpha-satellite DNA probes in the cytogenetic diagnosis. Standard banding cytogenetic techniques do not always allow to define the structure and the origin of chromosome rearrangements involving the centromere region. Non-isotopic in situ hybridization of alphoid sequences has allowed to determine the origin of the centromeres in the metaphases of 5 patients referred to us for: 2 structural rearrangements involving chromosome 21, 2 structural rearrangements involving chromosome Y and 1 reciprocal translocation involving on chromosome 20 and one chromosome 15.
|Translated title of the contribution||Non-radioactive in situ hybridization of alpha-satellite sequences in cytogenetic diagnosis|
|Number of pages||7|
|Publication status||Published - May 1992|
ASJC Scopus subject areas
- Pathology and Forensic Medicine