Ibridazione in situ non radioattiva di sequenze alfa-satellite nella diagnostica citogenetica.

Translated title of the contribution: Non-radioactive in situ hybridization of alpha-satellite sequences in cytogenetic diagnosis

C. Perfumo, A. Arslanian, F. Zara, G. Piombo, M. Pierluigi

Research output: Contribution to journalArticlepeer-review

Abstract

Non isotopic in situ hybridization with alpha-satellite DNA probes in the cytogenetic diagnosis. Standard banding cytogenetic techniques do not always allow to define the structure and the origin of chromosome rearrangements involving the centromere region. Non-isotopic in situ hybridization of alphoid sequences has allowed to determine the origin of the centromeres in the metaphases of 5 patients referred to us for: 2 structural rearrangements involving chromosome 21, 2 structural rearrangements involving chromosome Y and 1 reciprocal translocation involving on chromosome 20 and one chromosome 15.

Translated title of the contributionNon-radioactive in situ hybridization of alpha-satellite sequences in cytogenetic diagnosis
Original languageItalian
Pages (from-to)363-369
Number of pages7
JournalPathologica
Volume84
Issue number1091
Publication statusPublished - May 1992

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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