Non-radioactive nucleic acid probes: Labelling and detection procedures

Research output: Contribution to journalArticle

Abstract

A comprehensive overview is given concerning the in situ hybridization techniques using non-radioactively labelled probes. Details are given on the preparation of the probes with different reporter molecules and on the corresponding revealing assays. The development of non-isotopic labelling methods for nucleic acid probes has facilitated the diffusion of the in situ hybridization techniques to the research as well as to the clinical pathology laboratory. Non-radioactive probes have several advantages over the radiolabelled ones, including cost, shelf-life, safety and, last but not least, resolution of the signal.

Original languageEnglish
Pages (from-to)243-251
Number of pages9
JournalLiver
Volume12
Issue number4 II
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Hepatology

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