TY - JOUR
T1 - Non-random spatial relationships between mast cells and microvessels in human endometrial carcinoma
AU - Guidolin, Diego
AU - Marinaccio, Christian
AU - Tortorella, Cinzia
AU - Annese, Tiziana
AU - Ruggieri, Simona
AU - Finato, Nicoletta
AU - Crivellato, Enrico
AU - Ribatti, Domenico
PY - 2017/2
Y1 - 2017/2
N2 - Mast cells (MCs) accumulate in the stroma surrounding tumors, where they secrete angiogenic cytokines and proteases, and an increased number of MCs have been demonstrated in angiogenesis associated with solid and hematological tumors. The aim of this study is to contribute to the knowledge of distribution of MCs in tumors, investigating the pattern of distribution of tryptase-positive MCs around the blood vessels in human endometrial carcinoma samples by introducing a quantitative approach to characterize their spatial distribution. The results have shown that in human endometrial cancer bioptic specimens the spatial distribution of MCs shows significant deviation from randomness as compared with control group in which, instead, the spatial distribution of MCs is consistent with a random distribution. These findings confirm that MCs enhance tumor angiogenesis and their preferential localization along blood vessels and sites of new vessel formation sustaining the suggestion for an association between MCs and angiogenesis. However, this spatial association between vessels and MCs might simply reflect migrating MCs from the blood stream at vessel growing sites.
AB - Mast cells (MCs) accumulate in the stroma surrounding tumors, where they secrete angiogenic cytokines and proteases, and an increased number of MCs have been demonstrated in angiogenesis associated with solid and hematological tumors. The aim of this study is to contribute to the knowledge of distribution of MCs in tumors, investigating the pattern of distribution of tryptase-positive MCs around the blood vessels in human endometrial carcinoma samples by introducing a quantitative approach to characterize their spatial distribution. The results have shown that in human endometrial cancer bioptic specimens the spatial distribution of MCs shows significant deviation from randomness as compared with control group in which, instead, the spatial distribution of MCs is consistent with a random distribution. These findings confirm that MCs enhance tumor angiogenesis and their preferential localization along blood vessels and sites of new vessel formation sustaining the suggestion for an association between MCs and angiogenesis. However, this spatial association between vessels and MCs might simply reflect migrating MCs from the blood stream at vessel growing sites.
KW - Endometrial carcinoma
KW - Mast cell
KW - Spatial distribution
KW - Tumor growth
UR - http://www.scopus.com/inward/record.url?scp=84958755592&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958755592&partnerID=8YFLogxK
U2 - 10.1007/s10238-016-0407-4
DO - 10.1007/s10238-016-0407-4
M3 - Article
AN - SCOPUS:84958755592
VL - 17
SP - 71
EP - 77
JO - Zeitschrift für Die Gesamte Experimentelle Medizin
JF - Zeitschrift für Die Gesamte Experimentelle Medizin
SN - 1591-8890
IS - 1
ER -