Non-rash dermatologic adverse events related to targeted therapies

Objectives: To provide background information and management strategies for non-rash dermatological adverse events. Data Sources: Peer-reviewed journal articles, professional manuals, online sources. Conclusion: During the last decade, many dermatological adverse events of targeted therapy have been reported, including xerosis, skin fissures, pruritus, photosensitivity, pigmentation changes, hair and nail changes, hand-foot skin reaction, squamoproliferative lesions, Stevens-Johnsons syndrome, and toxic epidermal necrolysis. Although evidenced-based treatment options are scarce, many recommendations have been described in the literature that should be considered to apply in daily practice. Implications for Nursing Practice: Nursing practice will be enhanced by education, assessment, and management recommendations.