Non-resective surgery and radiosurgery for treatment of drug-resistant epilepsy

Pantaleo Romanelli, Pasquale Striano, Manlio Barbarisi, Giangennaro Coppola, David J. Anschel

Research output: Contribution to journalArticlepeer-review


Epilepsy surgery is an effective treatment for properly selected patients with intractable seizures. However, many patients with medically intractable epilepsy are not excellent candidates for surgical resection of the epileptogenic zone. Due to recent advances in computer technology and bioengineering, several novel techniques are receiving increasing interest for their role in the care of people with epilepsy. Neuromodulation is an emerging surgical option to be used when conventional resective surgery is not indicated. We review the indications and expected outcomes of neuromodulatory treatments currently available for the treatment of refractory epilepsy, i.e., vagus nerve stimulation, deep brain stimulation, stereotactic radiosurgery, and multiple subpial transections.

Original languageEnglish
Pages (from-to)193-201
Number of pages9
JournalEpilepsy Research
Issue number3
Publication statusPublished - May 2012


  • Deep brain stimulation
  • Epilepsy
  • Multiple subpial transections
  • Neuromodulation
  • Stereotactic radiosurgery
  • Vagal nerve stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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