TY - JOUR
T1 - Non-respiratory components of heart rate variability in heart transplant recipients
T2 - Evidence of autonomic reinnervation?
AU - Bernardi, L.
AU - Valle, F.
AU - Leuzzi, S.
AU - Rinaldi, M.
AU - Marchesi, E.
AU - Falcone, C.
AU - Martinelli, L.
AU - Vigano, M.
AU - Finardi, G.
AU - Radaelli, A.
PY - 1994
Y1 - 1994
N2 - 1. Although the high-frequency fluctuations in R-R interval (respiratory sinus arrhythmia) observed in heart transplant recipients are not a reliable marker of reinnervation because of a previously shown direct mechanical effect of breathing, the presence of a non-respiration-related low-frequency oscillation reflects rhythms generated outside the heart, and thus could be neurally mediated. 2. To evaluate the presence of reinnervation, the spontaneous variability in R-R interval was investigated, supine and after passive tilting, in 23 heart transplant recipients (age 43 years, range 23- 64 years) and in 25 normotensive control subjects by autoregressive spectral analysis of low- and high-frequency spontaneous fluctuations in R-R interval and respiration. The response of R-R interval to amyl nitrite inhalation was also evaluated in five heart transplant recipients and eight control subjects. 3. Detectable low-frequency oscillations, unrelated to respiration, were present in 13/23 heart transplant recipients, particularly in those who were transplanted at least 20 months earlier (11/14). The natural logarithm of the power of low-frequency fluctuations was markedly lower than in control subjects (0.75±0.21 versus 5.62±0.20 ms2, P
AB - 1. Although the high-frequency fluctuations in R-R interval (respiratory sinus arrhythmia) observed in heart transplant recipients are not a reliable marker of reinnervation because of a previously shown direct mechanical effect of breathing, the presence of a non-respiration-related low-frequency oscillation reflects rhythms generated outside the heart, and thus could be neurally mediated. 2. To evaluate the presence of reinnervation, the spontaneous variability in R-R interval was investigated, supine and after passive tilting, in 23 heart transplant recipients (age 43 years, range 23- 64 years) and in 25 normotensive control subjects by autoregressive spectral analysis of low- and high-frequency spontaneous fluctuations in R-R interval and respiration. The response of R-R interval to amyl nitrite inhalation was also evaluated in five heart transplant recipients and eight control subjects. 3. Detectable low-frequency oscillations, unrelated to respiration, were present in 13/23 heart transplant recipients, particularly in those who were transplanted at least 20 months earlier (11/14). The natural logarithm of the power of low-frequency fluctuations was markedly lower than in control subjects (0.75±0.21 versus 5.62±0.20 ms2, P
KW - autonomic nervous system
KW - heart rate variability
KW - heart transplantation
KW - power spectrum analysis
KW - reinnervation
KW - respiratory sinus arrhythmia
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M3 - Article
C2 - 7913430
AN - SCOPUS:0028298435
VL - 86
SP - 537
EP - 545
JO - Clinical Science
JF - Clinical Science
SN - 0143-5221
IS - 5
ER -