Abstract
Cell migration is fundamental for numerous biological processes and is critical for the pathogenesis of several diseases. Chemokines represent the main class of mediators providing cell directional migration and several levels of regulation of their function have been identified. A subfamily of chemokine receptors not able to transduce chemotactic signals plays an important role in the control of chemokine concentrations through binding, internalization and degradation of chemotactic factors. Here we review in vitro and in vivo evidences indicating that these 'silent' chemokine receptors represent a strategy to regulate innate and adaptive immunity.
Original language | English |
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Pages (from-to) | 14-19 |
Number of pages | 6 |
Journal | Journal of Neuroimmunology |
Volume | 198 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - Jul 31 2008 |
Keywords
- Chemokine
- Decoy receptor
- Inflammation
- Scavenger receptor
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology