Non-signaling chemokine receptors: Mechanism of action and role in vivo

Raffaella Bonecchi; Elena M. Borroni; Benedetta Savino; Chiara Buracchi; Alberto Mantovani; Massimo Locati

doi:10.1016/j.jneuroim.2008.04.018

Non-signaling chemokine receptors: Mechanism of action and role in vivo

Raffaella Bonecchi, Elena M. Borroni, Benedetta Savino, Chiara Buracchi, Alberto Mantovani, Massimo Locati

Istituto Clinico Humanitas

Research output: Contribution to journal › Article

Abstract

Cell migration is fundamental for numerous biological processes and is critical for the pathogenesis of several diseases. Chemokines represent the main class of mediators providing cell directional migration and several levels of regulation of their function have been identified. A subfamily of chemokine receptors not able to transduce chemotactic signals plays an important role in the control of chemokine concentrations through binding, internalization and degradation of chemotactic factors. Here we review in vitro and in vivo evidences indicating that these 'silent' chemokine receptors represent a strategy to regulate innate and adaptive immunity.

Original language	English
Pages (from-to)	14-19
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	198
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2008.04.018
Publication status	Published - Jul 31 2008

Keywords

Chemokine
Decoy receptor
Inflammation
Scavenger receptor

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

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Bonecchi, R., Borroni, E. M., Savino, B., Buracchi, C., Mantovani, A., & Locati, M. (2008). Non-signaling chemokine receptors: Mechanism of action and role in vivo. Journal of Neuroimmunology, 198(1-2), 14-19. https://doi.org/10.1016/j.jneuroim.2008.04.018

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AU - Locati, Massimo

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