Non-small cell lung cancer in a very young woman: A case report and critical review of the literature

Valentina Polo, Giulia Zago, Stefano Frega, Fabio Canova, Laura Bonanno, Adolfo Favaretto, Laura Bonaldi, Roberta Bertorelle, PierFranco Conte, Giulia Pasello

Research output: Contribution to journalArticlepeer-review


Objective: Unusual clinical course Background: Lung cancer in young patients is quite uncommon; clinical presentation and outcome in this population compared to the older group are not yet well defined and data about this setting are mostly single-institutional retrospective analyses. Case Report: We report here a case of a very young woman with diagnosis of early-stage lung adenocarcinoma harboring EML4-ALK rearrangement; she underwent radical surgery and adjuvant chemotherapy according to the pathologic stage. Potential risk factors for lung cancer in our patient are discussed and clinico-pathologic features and outcomes of lung cancer in the young population compared to the elderly are reviewed through discussing studies with sample sizes larger than 100 patients. Conclusions: A wide clinical overview should be performed when lung cancer is diagnosed in a young patient. Large-population studies are required to define the molecular signature and clinical behavior of lung cancer in young patients.

Original languageEnglish
Pages (from-to)782-789
Number of pages8
JournalAmerican Journal of Case Reports
Publication statusPublished - Nov 3 2015


  • Lung neoplasms
  • Patient outcome assessment
  • Risk factors
  • Young adult

ASJC Scopus subject areas

  • Medicine(all)


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