Non-steroidal anti-inflammatory drug use in the elderly

Alberto Pilotto, Daniele Sancarlo, Filomena Addante, Carlo Scarcelli, Marilisa Franceschi

Research output: Contribution to journalArticlepeer-review


The efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of inflammation and pain of various origins is well established. Prescribing these drugs, however, remains a challenge because a great variety of gastrointestinal and cardiovascular safety issues need to be considered, particularly in older patients. Recent recommendations suggest that the prescription of non-selective NSAIDs and/or selective cyclo-oxygenase-2 inhibitors (coxibs) may be appropriate in patients with low gastrointestinal risk (no prior gastrointestinal events, no concomitant treatments with other damaging drugs). Gastroprotection is appropriate in patients with gastrointestinal risk factors and in older patients. In patients at high risk for gastrointestinal and cardiovascular events, however, NSAID or coxib prescriptions are contraindicated. Multidimensional impairment is a crucial point in evaluating the clinical outcome of older patients; thus, a comprehensive geriatric assessment is useful in predicting adverse outcomes, including morbidity and mortality.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalSurgical Oncology
Issue number3
Publication statusPublished - Sep 2010


  • Elderly
  • Pain

ASJC Scopus subject areas

  • Oncology
  • Surgery


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