Abstract
The efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of inflammation and pain of various origins is well established. Prescribing these drugs, however, remains a challenge because a great variety of gastrointestinal and cardiovascular safety issues need to be considered, particularly in older patients. Recent recommendations suggest that the prescription of non-selective NSAIDs and/or selective cyclo-oxygenase-2 inhibitors (coxibs) may be appropriate in patients with low gastrointestinal risk (no prior gastrointestinal events, no concomitant treatments with other damaging drugs). Gastroprotection is appropriate in patients with gastrointestinal risk factors and in older patients. In patients at high risk for gastrointestinal and cardiovascular events, however, NSAID or coxib prescriptions are contraindicated. Multidimensional impairment is a crucial point in evaluating the clinical outcome of older patients; thus, a comprehensive geriatric assessment is useful in predicting adverse outcomes, including morbidity and mortality.
| Original language | English |
|---|---|
| Pages (from-to) | 167-172 |
| Number of pages | 6 |
| Journal | Surgical Oncology |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2010 |
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Keywords
- Elderly
- NSAID
- Pain
ASJC Scopus subject areas
- Oncology
- Surgery
Cite this
Non-steroidal anti-inflammatory drug use in the elderly. / Pilotto, Alberto; Sancarlo, Daniele; Addante, Filomena; Scarcelli, Carlo; Franceschi, Marilisa.
In: Surgical Oncology, Vol. 19, No. 3, 09.2010, p. 167-172.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Non-steroidal anti-inflammatory drug use in the elderly
AU - Pilotto, Alberto
AU - Sancarlo, Daniele
AU - Addante, Filomena
AU - Scarcelli, Carlo
AU - Franceschi, Marilisa
PY - 2010/9
Y1 - 2010/9
N2 - The efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of inflammation and pain of various origins is well established. Prescribing these drugs, however, remains a challenge because a great variety of gastrointestinal and cardiovascular safety issues need to be considered, particularly in older patients. Recent recommendations suggest that the prescription of non-selective NSAIDs and/or selective cyclo-oxygenase-2 inhibitors (coxibs) may be appropriate in patients with low gastrointestinal risk (no prior gastrointestinal events, no concomitant treatments with other damaging drugs). Gastroprotection is appropriate in patients with gastrointestinal risk factors and in older patients. In patients at high risk for gastrointestinal and cardiovascular events, however, NSAID or coxib prescriptions are contraindicated. Multidimensional impairment is a crucial point in evaluating the clinical outcome of older patients; thus, a comprehensive geriatric assessment is useful in predicting adverse outcomes, including morbidity and mortality.
AB - The efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of inflammation and pain of various origins is well established. Prescribing these drugs, however, remains a challenge because a great variety of gastrointestinal and cardiovascular safety issues need to be considered, particularly in older patients. Recent recommendations suggest that the prescription of non-selective NSAIDs and/or selective cyclo-oxygenase-2 inhibitors (coxibs) may be appropriate in patients with low gastrointestinal risk (no prior gastrointestinal events, no concomitant treatments with other damaging drugs). Gastroprotection is appropriate in patients with gastrointestinal risk factors and in older patients. In patients at high risk for gastrointestinal and cardiovascular events, however, NSAID or coxib prescriptions are contraindicated. Multidimensional impairment is a crucial point in evaluating the clinical outcome of older patients; thus, a comprehensive geriatric assessment is useful in predicting adverse outcomes, including morbidity and mortality.
KW - Elderly
KW - NSAID
KW - Pain
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UR - http://www.scopus.com/inward/citedby.url?scp=77955920715&partnerID=8YFLogxK
U2 - 10.1016/j.suronc.2009.11.014
DO - 10.1016/j.suronc.2009.11.014
M3 - Article
C2 - 20022240
AN - SCOPUS:77955920715
VL - 19
SP - 167
EP - 172
JO - Surgical Oncology
JF - Surgical Oncology
SN - 0960-7404
IS - 3
ER -