Non-steroidal anti-inflammatory drugs as the first step in cancer pain therapy: double-blind, within-patient study comparing nine drugs

V. Ventafridda, F. De Conno, A. E. Panerai, V. Maresca, G. C. Monza, C. Ripamonti

Research output: Contribution to journalArticlepeer-review

Abstract

The efficacy and tolerability of acetylsalicylic acid, paracetamol, diclofenac, ibuprofen, indomethacin, pirprofen, sulindac, naproxen and suprofen were compared in the treatment of cancer pain. In a double-blind, within-patient randomized study, each drug was given for 1 week to eight patients and for another week to a further eight patients. A total of 65 patients were effectively treated; only 48 completed week 1 and 41 completed week 2. Naproxen, diclofenac and indomethacin were highly effective in pain relief (tested by means of a 100 mm visual analogue scale) and were relatively well tolerated. It is concluded that these non-steroidal anti-inflammatory drugs can be considered as first choice in the treatment of cancer pain.

Original languageEnglish
Pages (from-to)21-29
Number of pages9
JournalJournal of International Medical Research
Volume18
Issue number1
Publication statusPublished - 1990

Keywords

  • cancer pain
  • Non-steroidal anti-inflammatory drugs

ASJC Scopus subject areas

  • Medicine(all)

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