Non-surgical treatment of chondrosarcoma: Current concepts and future perspectives

Eric L. Staals, Emanuela Palmerini, Stefano Ferrari, Mario Mercuri

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Chondrosarcoma represents a heterogeneous group of malignant cartilage tumors. Surgery is the most important component of treatment. Although convincing evidence of its benefit is lacking, chemotherapy might be useful in the treatment of mesenchymal and dedifferentiated chondrosarcoma. Radiotherapy plays an important role in the treatment of chondrosarcomas located in the spheno-occipital region and cervical spine. New modern radiation techniques could further improve the outcome for patients with lesions in sites that are surgically difficult to access. Finally, better understanding of molecular diagnostics and pathogenesis of chondrosarcoma, together with the development of new therapeutic agents, has resulted in numerous studies investigating potentially active treatment approaches to this disease. However, at present, the majority of these new compounds are being tested in preclinical settings, and their future clinical application still needs to be defined.

Original languageEnglish
Title of host publicationBone Cancer
PublisherElsevier Inc.
Pages375-383
Number of pages9
ISBN (Print)9780123748959
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

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