Non-surgically related causes of erectile dysfunction after bilateral nerve-sparing radical prostatectomy

Giorgio Gandaglia, G. Lista, N. Fossati, N. Suardi, A. Gallina, M. Moschini, L. Bianchi, M. S. Rossi, R. Schiavina, S. F. Shariat, A. Salonia, F. Montorsi, A. Briganti

Research output: Contribution to journalArticlepeer-review


Background:Erectile dysfunction (ED) represents one of the most common long-term side effects in prostate cancer (PCa) patients treated with bilateral nerve-sparing radical prostatectomy (BNSRP). The aim of our study was to assess the influence of non-surgically related causes of ED in patients treated with BNSRP.Methods:Overall, 716 patients treated with BNSRP were retrospectively identified. All patients had complete data on erectile function (EF) assessed by the Index of Erectile Function-EF domain (IIEF-EF) and depressive status assessed by the Center for Epidemiologic Studies-Depression (CES-D) questionnaire. EF recovery was defined as an IIEF-EF of ⩾22. Kaplan–Meier analyses assessed the impact of preoperative IIEF-EF, depression and adjuvant radiotherapy (aRT) on the time to EF recovery. Multivariable Cox regression models were used to test the impact of aRT on EF recovery after accounting for depression and baseline IIEF-EF.Results:Median follow-up was 48 months. Patients with a preoperative IIEF-EF of ⩾22 had substantially higher EF recovery rates compared with those with a lower IIEF-EF (P

Original languageEnglish
JournalProstate Cancer and Prostatic Diseases
Publication statusAccepted/In press - Feb 9 2016

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research


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