Nonalcoholic fatty liver disease: A challenge for pediatricians

Valerio Nobili, Naim Alkhouri, Anna Alisi, Claudia Della Corte, Emer Fitzpatrick, Massimiliano Raponi, Anil Dhawan

Research output: Contribution to journalArticlepeer-review

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and is considered the most common form of chronic liver disease in children. Several factors contribute to NAFLD development, including race/ethnicity, genetic factors, environmental exposures, and alterations in the gut microbiome. The histologic spectrum of NAFLD ranges from simple steatosis to the more aggressive nonalcoholic steatohepatitis (NASH). Fibrosis and eventually cirrhosis can develop from NAFLD during childhood. Diagnosing advanced disease is challenging and may require a liver biopsy, highlighting the urgent need for reliable, noninvasive markers of disease severity. The mainstay of treatment for NAFLD remains lifestyle modifications and weight loss. Probiotics and ω-3 fatty acids may ameliorate disease progression. Recent data have suggested that vitamin Emay be considered as a NASH-specific therapy in children, and there are several ongoing human studies evaluating different therapeutic targets for NAFLD.We provide an up-to-date review of the risk factors, diagnosis, and treatment to manage this common disease in children.

Original languageEnglish
Pages (from-to)170-176
Number of pages7
JournalJAMA Pediatrics
Volume169
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Nonalcoholic fatty liver disease: A challenge for pediatricians'. Together they form a unique fingerprint.

Cite this