Abstract
BACKGROUND Nonalcoholic fatty liver disease (NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease (ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the most common cause of ESLD in Western countries, becoming a serious public health concern. Hidradenitis suppurativa (HS) is a systemic inflammatory/autoinflammatory disease of the terminal follicular epithelium of the apocrine gland with a prevalence of 0.05% to 4.10%. Due to its systemic inflammatory behavior several comorbidities were recently associated, however liver ones were scarcely assessed. AIM To evaluate the prevalence and characteristics of NASH/NAFL in HS patients. METHODS This retrospective study is a sub-analysis of a larger study carried out in 4 Italian dermatological centers. In this cohort, there were 83 patients: 51 patients with HS only, 20 patients with HS/NAFL and 12 with HS/NASH. RESULTS Inflammatory comorbidities were present in 3.9% of HS only patients, 25% of HS/NAFL patients and 58.3% of HS/NASH patients (P < 0.001). Similarly, mean Autoinflammatory Disease Damage Index (ADDI) was significantly higher among patients with HS/NASH (5.3 ± 2.2, P < 0.001) compared to patients with HS/NAFL or HS only (2.8 ± 1.6 and 2.6 ± 1.4 respectively). Furthermore, ADDI correlates with IHS4 in HS, HS/NAFL and HS/NASH. Diabetic patients have higher Hurley score than not diabetic ones. Ultrasound examination was significantly different in the three groups. CONCLUSION HS patients displayed a high prevalence of NASH/NAFLD and ultrasound examination should be particularly addressed to patients that display high ADDI scores.
| Original language | English |
|---|---|
| Pages (from-to) | 391-401 |
| Number of pages | 11 |
| Journal | World Journal of Hepatology |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1 2019 |
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Keywords
- End stage liver disease
- Hidradenitis suppurativa
- Non-alcoholic fatty liver
- Non-alcoholic steatohepatitis
- Nonalcoholic fatty liver disease
ASJC Scopus subject areas
- Hepatology
Cite this
Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa : A multi-center retrospective analysis. / Damiani, Giovanni; Leone, Sebastiano; Fajgenbaum, Kristen; Bragazzi, Nicola L.; Pacifico, Alessia; Conic, Rosalynn R.Z.; Pigatto, Paolo D.M.; Maiorana, Carlo; Poli, Pierpaolo; Berti, Emilio; Pace, Maria C.; Malagoli, Piergiorgio; Bettoli, Vincenzo; Fiore, Marco.
In: World Journal of Hepatology, Vol. 11, No. 4, 01.04.2019, p. 391-401.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa
T2 - A multi-center retrospective analysis
AU - Damiani, Giovanni
AU - Leone, Sebastiano
AU - Fajgenbaum, Kristen
AU - Bragazzi, Nicola L.
AU - Pacifico, Alessia
AU - Conic, Rosalynn R.Z.
AU - Pigatto, Paolo D.M.
AU - Maiorana, Carlo
AU - Poli, Pierpaolo
AU - Berti, Emilio
AU - Pace, Maria C.
AU - Malagoli, Piergiorgio
AU - Bettoli, Vincenzo
AU - Fiore, Marco
PY - 2019/4/1
Y1 - 2019/4/1
N2 - BACKGROUND Nonalcoholic fatty liver disease (NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease (ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the most common cause of ESLD in Western countries, becoming a serious public health concern. Hidradenitis suppurativa (HS) is a systemic inflammatory/autoinflammatory disease of the terminal follicular epithelium of the apocrine gland with a prevalence of 0.05% to 4.10%. Due to its systemic inflammatory behavior several comorbidities were recently associated, however liver ones were scarcely assessed. AIM To evaluate the prevalence and characteristics of NASH/NAFL in HS patients. METHODS This retrospective study is a sub-analysis of a larger study carried out in 4 Italian dermatological centers. In this cohort, there were 83 patients: 51 patients with HS only, 20 patients with HS/NAFL and 12 with HS/NASH. RESULTS Inflammatory comorbidities were present in 3.9% of HS only patients, 25% of HS/NAFL patients and 58.3% of HS/NASH patients (P < 0.001). Similarly, mean Autoinflammatory Disease Damage Index (ADDI) was significantly higher among patients with HS/NASH (5.3 ± 2.2, P < 0.001) compared to patients with HS/NAFL or HS only (2.8 ± 1.6 and 2.6 ± 1.4 respectively). Furthermore, ADDI correlates with IHS4 in HS, HS/NAFL and HS/NASH. Diabetic patients have higher Hurley score than not diabetic ones. Ultrasound examination was significantly different in the three groups. CONCLUSION HS patients displayed a high prevalence of NASH/NAFLD and ultrasound examination should be particularly addressed to patients that display high ADDI scores.
AB - BACKGROUND Nonalcoholic fatty liver disease (NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease (ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the most common cause of ESLD in Western countries, becoming a serious public health concern. Hidradenitis suppurativa (HS) is a systemic inflammatory/autoinflammatory disease of the terminal follicular epithelium of the apocrine gland with a prevalence of 0.05% to 4.10%. Due to its systemic inflammatory behavior several comorbidities were recently associated, however liver ones were scarcely assessed. AIM To evaluate the prevalence and characteristics of NASH/NAFL in HS patients. METHODS This retrospective study is a sub-analysis of a larger study carried out in 4 Italian dermatological centers. In this cohort, there were 83 patients: 51 patients with HS only, 20 patients with HS/NAFL and 12 with HS/NASH. RESULTS Inflammatory comorbidities were present in 3.9% of HS only patients, 25% of HS/NAFL patients and 58.3% of HS/NASH patients (P < 0.001). Similarly, mean Autoinflammatory Disease Damage Index (ADDI) was significantly higher among patients with HS/NASH (5.3 ± 2.2, P < 0.001) compared to patients with HS/NAFL or HS only (2.8 ± 1.6 and 2.6 ± 1.4 respectively). Furthermore, ADDI correlates with IHS4 in HS, HS/NAFL and HS/NASH. Diabetic patients have higher Hurley score than not diabetic ones. Ultrasound examination was significantly different in the three groups. CONCLUSION HS patients displayed a high prevalence of NASH/NAFLD and ultrasound examination should be particularly addressed to patients that display high ADDI scores.
KW - End stage liver disease
KW - Hidradenitis suppurativa
KW - Non-alcoholic fatty liver
KW - Non-alcoholic steatohepatitis
KW - Nonalcoholic fatty liver disease
UR - http://www.scopus.com/inward/record.url?scp=85065777711&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065777711&partnerID=8YFLogxK
U2 - 10.4254/wjh.v11.i4.391
DO - 10.4254/wjh.v11.i4.391
M3 - Article
VL - 11
SP - 391
EP - 401
JO - World Journal of Hepatology
JF - World Journal of Hepatology
SN - 1948-5182
IS - 4
ER -