Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa

A multi-center retrospective analysis

Giovanni Damiani, Sebastiano Leone, Kristen Fajgenbaum, Nicola L. Bragazzi, Alessia Pacifico, Rosalynn R.Z. Conic, Paolo D.M. Pigatto, Carlo Maiorana, Pierpaolo Poli, Emilio Berti, Maria C. Pace, Piergiorgio Malagoli, Vincenzo Bettoli, Marco Fiore

Research output: Contribution to journalArticle

Abstract

BACKGROUND Nonalcoholic fatty liver disease (NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease (ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the most common cause of ESLD in Western countries, becoming a serious public health concern. Hidradenitis suppurativa (HS) is a systemic inflammatory/autoinflammatory disease of the terminal follicular epithelium of the apocrine gland with a prevalence of 0.05% to 4.10%. Due to its systemic inflammatory behavior several comorbidities were recently associated, however liver ones were scarcely assessed. AIM To evaluate the prevalence and characteristics of NASH/NAFL in HS patients. METHODS This retrospective study is a sub-analysis of a larger study carried out in 4 Italian dermatological centers. In this cohort, there were 83 patients: 51 patients with HS only, 20 patients with HS/NAFL and 12 with HS/NASH. RESULTS Inflammatory comorbidities were present in 3.9% of HS only patients, 25% of HS/NAFL patients and 58.3% of HS/NASH patients (P < 0.001). Similarly, mean Autoinflammatory Disease Damage Index (ADDI) was significantly higher among patients with HS/NASH (5.3 ± 2.2, P < 0.001) compared to patients with HS/NAFL or HS only (2.8 ± 1.6 and 2.6 ± 1.4 respectively). Furthermore, ADDI correlates with IHS4 in HS, HS/NAFL and HS/NASH. Diabetic patients have higher Hurley score than not diabetic ones. Ultrasound examination was significantly different in the three groups. CONCLUSION HS patients displayed a high prevalence of NASH/NAFLD and ultrasound examination should be particularly addressed to patients that display high ADDI scores.

Original languageEnglish
Pages (from-to)391-401
Number of pages11
JournalWorld Journal of Hepatology
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 1 2019

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Hidradenitis Suppurativa
Fatty Liver
Alcoholic Fatty Liver
End Stage Liver Disease
Non-alcoholic Fatty Liver Disease
Comorbidity
Apocrine Glands

Keywords

  • End stage liver disease
  • Hidradenitis suppurativa
  • Non-alcoholic fatty liver
  • Non-alcoholic steatohepatitis
  • Nonalcoholic fatty liver disease

ASJC Scopus subject areas

  • Hepatology

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Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa : A multi-center retrospective analysis. / Damiani, Giovanni; Leone, Sebastiano; Fajgenbaum, Kristen; Bragazzi, Nicola L.; Pacifico, Alessia; Conic, Rosalynn R.Z.; Pigatto, Paolo D.M.; Maiorana, Carlo; Poli, Pierpaolo; Berti, Emilio; Pace, Maria C.; Malagoli, Piergiorgio; Bettoli, Vincenzo; Fiore, Marco.

In: World Journal of Hepatology, Vol. 11, No. 4, 01.04.2019, p. 391-401.

Research output: Contribution to journalArticle

Damiani, G, Leone, S, Fajgenbaum, K, Bragazzi, NL, Pacifico, A, Conic, RRZ, Pigatto, PDM, Maiorana, C, Poli, P, Berti, E, Pace, MC, Malagoli, P, Bettoli, V & Fiore, M 2019, 'Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis', World Journal of Hepatology, vol. 11, no. 4, pp. 391-401. https://doi.org/10.4254/wjh.v11.i4.391
Damiani, Giovanni ; Leone, Sebastiano ; Fajgenbaum, Kristen ; Bragazzi, Nicola L. ; Pacifico, Alessia ; Conic, Rosalynn R.Z. ; Pigatto, Paolo D.M. ; Maiorana, Carlo ; Poli, Pierpaolo ; Berti, Emilio ; Pace, Maria C. ; Malagoli, Piergiorgio ; Bettoli, Vincenzo ; Fiore, Marco. / Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa : A multi-center retrospective analysis. In: World Journal of Hepatology. 2019 ; Vol. 11, No. 4. pp. 391-401.
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abstract = "BACKGROUND Nonalcoholic fatty liver disease (NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease (ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the most common cause of ESLD in Western countries, becoming a serious public health concern. Hidradenitis suppurativa (HS) is a systemic inflammatory/autoinflammatory disease of the terminal follicular epithelium of the apocrine gland with a prevalence of 0.05{\%} to 4.10{\%}. Due to its systemic inflammatory behavior several comorbidities were recently associated, however liver ones were scarcely assessed. AIM To evaluate the prevalence and characteristics of NASH/NAFL in HS patients. METHODS This retrospective study is a sub-analysis of a larger study carried out in 4 Italian dermatological centers. In this cohort, there were 83 patients: 51 patients with HS only, 20 patients with HS/NAFL and 12 with HS/NASH. RESULTS Inflammatory comorbidities were present in 3.9{\%} of HS only patients, 25{\%} of HS/NAFL patients and 58.3{\%} of HS/NASH patients (P < 0.001). Similarly, mean Autoinflammatory Disease Damage Index (ADDI) was significantly higher among patients with HS/NASH (5.3 ± 2.2, P < 0.001) compared to patients with HS/NAFL or HS only (2.8 ± 1.6 and 2.6 ± 1.4 respectively). Furthermore, ADDI correlates with IHS4 in HS, HS/NAFL and HS/NASH. Diabetic patients have higher Hurley score than not diabetic ones. Ultrasound examination was significantly different in the three groups. CONCLUSION HS patients displayed a high prevalence of NASH/NAFLD and ultrasound examination should be particularly addressed to patients that display high ADDI scores.",
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T1 - Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa

T2 - A multi-center retrospective analysis

AU - Damiani, Giovanni

AU - Leone, Sebastiano

AU - Fajgenbaum, Kristen

AU - Bragazzi, Nicola L.

AU - Pacifico, Alessia

AU - Conic, Rosalynn R.Z.

AU - Pigatto, Paolo D.M.

AU - Maiorana, Carlo

AU - Poli, Pierpaolo

AU - Berti, Emilio

AU - Pace, Maria C.

AU - Malagoli, Piergiorgio

AU - Bettoli, Vincenzo

AU - Fiore, Marco

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N2 - BACKGROUND Nonalcoholic fatty liver disease (NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease (ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the most common cause of ESLD in Western countries, becoming a serious public health concern. Hidradenitis suppurativa (HS) is a systemic inflammatory/autoinflammatory disease of the terminal follicular epithelium of the apocrine gland with a prevalence of 0.05% to 4.10%. Due to its systemic inflammatory behavior several comorbidities were recently associated, however liver ones were scarcely assessed. AIM To evaluate the prevalence and characteristics of NASH/NAFL in HS patients. METHODS This retrospective study is a sub-analysis of a larger study carried out in 4 Italian dermatological centers. In this cohort, there were 83 patients: 51 patients with HS only, 20 patients with HS/NAFL and 12 with HS/NASH. RESULTS Inflammatory comorbidities were present in 3.9% of HS only patients, 25% of HS/NAFL patients and 58.3% of HS/NASH patients (P < 0.001). Similarly, mean Autoinflammatory Disease Damage Index (ADDI) was significantly higher among patients with HS/NASH (5.3 ± 2.2, P < 0.001) compared to patients with HS/NAFL or HS only (2.8 ± 1.6 and 2.6 ± 1.4 respectively). Furthermore, ADDI correlates with IHS4 in HS, HS/NAFL and HS/NASH. Diabetic patients have higher Hurley score than not diabetic ones. Ultrasound examination was significantly different in the three groups. CONCLUSION HS patients displayed a high prevalence of NASH/NAFLD and ultrasound examination should be particularly addressed to patients that display high ADDI scores.

AB - BACKGROUND Nonalcoholic fatty liver disease (NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease (ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the most common cause of ESLD in Western countries, becoming a serious public health concern. Hidradenitis suppurativa (HS) is a systemic inflammatory/autoinflammatory disease of the terminal follicular epithelium of the apocrine gland with a prevalence of 0.05% to 4.10%. Due to its systemic inflammatory behavior several comorbidities were recently associated, however liver ones were scarcely assessed. AIM To evaluate the prevalence and characteristics of NASH/NAFL in HS patients. METHODS This retrospective study is a sub-analysis of a larger study carried out in 4 Italian dermatological centers. In this cohort, there were 83 patients: 51 patients with HS only, 20 patients with HS/NAFL and 12 with HS/NASH. RESULTS Inflammatory comorbidities were present in 3.9% of HS only patients, 25% of HS/NAFL patients and 58.3% of HS/NASH patients (P < 0.001). Similarly, mean Autoinflammatory Disease Damage Index (ADDI) was significantly higher among patients with HS/NASH (5.3 ± 2.2, P < 0.001) compared to patients with HS/NAFL or HS only (2.8 ± 1.6 and 2.6 ± 1.4 respectively). Furthermore, ADDI correlates with IHS4 in HS, HS/NAFL and HS/NASH. Diabetic patients have higher Hurley score than not diabetic ones. Ultrasound examination was significantly different in the three groups. CONCLUSION HS patients displayed a high prevalence of NASH/NAFLD and ultrasound examination should be particularly addressed to patients that display high ADDI scores.

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KW - Hidradenitis suppurativa

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KW - Non-alcoholic steatohepatitis

KW - Nonalcoholic fatty liver disease

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