Noncoding RNAs as circulating biomarkers in osteosarcoma patients

Research output: Contribution to journalReview articlepeer-review

Abstract

Noncoding RNAs (ncRNAs) identify a large family of RNAs that do not encode proteins and represent an important group of tumor biomarkers, directly involved in the process of tumor pathogenesis and progression. Many of them have also been identified in biological fluids of patients with cancer, especially blood, suggesting their role as an emerging class of circulating biomarkers. Many ncRNAs, both miRNAs and lncRNAs, are deregulated in sarcoma tissues, with the most consistent data in osteosarcomas. In patients with osteosarcoma, the role of ncRNAs as circulating biomarkers is taking enormous value, above all for their ability to vary expression levels during disease progression and in response to therapy. In this mini-review, we summarize the main studies supporting the role of circulating ncRNAs in monitoring disease status in patients with osteosarcoma.

Original languageEnglish
Pages (from-to)19249-19255
Number of pages7
JournalJournal of Cellular Physiology
Volume234
Issue number11
DOIs
Publication statusPublished - Nov 1 2019

Keywords

  • circulating miRNAs
  • circulating ncRNAs
  • osteosarcoma

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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