TY - JOUR
T1 - Noncoding RNAs
T2 - Emerging players in muscular dystrophies
AU - Falcone, Germana
AU - Perfetti, Alessandra
AU - Cardinali, Beatrice
AU - Martelli, Fabio
PY - 2014
Y1 - 2014
N2 - The fascinating world of noncoding RNAs has recently come to light, thanks to the development of powerful sequencing technologies, revealing a variety of RNA molecules playing important regulatory functions in most, if not all, cellular processes. Many noncoding RNAs have been implicated in regulatory networks that are determinant for skeletal muscle differentiation and disease. In this review, we outline the noncoding RNAs involved in physiological mechanisms of myogenesis and those that appear dysregulated in muscle dystrophies, also discussing their potential use as disease biomarkers and therapeutic targets.
AB - The fascinating world of noncoding RNAs has recently come to light, thanks to the development of powerful sequencing technologies, revealing a variety of RNA molecules playing important regulatory functions in most, if not all, cellular processes. Many noncoding RNAs have been implicated in regulatory networks that are determinant for skeletal muscle differentiation and disease. In this review, we outline the noncoding RNAs involved in physiological mechanisms of myogenesis and those that appear dysregulated in muscle dystrophies, also discussing their potential use as disease biomarkers and therapeutic targets.
UR - http://www.scopus.com/inward/record.url?scp=84897901920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897901920&partnerID=8YFLogxK
U2 - 10.1155/2014/503634
DO - 10.1155/2014/503634
M3 - Article
C2 - 24729974
AN - SCOPUS:84897901920
VL - 2014
JO - BioMed Research International
JF - BioMed Research International
SN - 2314-6133
M1 - 503634
ER -