Noncoding RNAs implication in cardiovascular diseases in the COVID-19 era

S Greco, A Madè, C Gaetano, Y Devaux, C Emanueli, F Martelli

Research output: Contribution to journalReview articlepeer-review

Abstract

COronaVIrus Disease 19 (COVID-19) is caused by the infection of the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2). Although the main clinical manifestations of COVID-19 are respiratory, many patients also display acute myocardial injury and chronic damage to the cardiovascular system. Understanding both direct and indirect damage caused to the heart and the vascular system by SARS-CoV-2 infection is necessary to identify optimal clinical care strategies. The homeostasis of the cardiovascular system requires a tight regulation of the gene expression, which is controlled by multiple types of RNA molecules, including RNA encoding proteins (messenger RNAs) (mRNAs) and those lacking protein-coding potential, the noncoding-RNAs. In the last few years, dysregulation of noncoding-RNAs has emerged as a crucial component in the pathophysiology of virtually all cardiovascular diseases. Here we will discuss the potential role of noncoding RNAs in COVID-19 disease mechanisms and their possible use as biomarkers of clinical use.

Original languageEnglish
Pages (from-to)408
JournalJournal of Translational Medicine
Volume18
Issue number1
DOIs
Publication statusPublished - Oct 31 2020

Keywords

  • Animals
  • Arrhythmias, Cardiac/complications
  • Betacoronavirus
  • Cardiomegaly/complications
  • Cardiovascular Diseases/complications
  • Coronavirus Infections/complications
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Homeostasis
  • Humans
  • Inflammation/complications
  • Mice
  • Pandemics
  • Peptidyl-Dipeptidase A/genetics
  • Pneumonia, Viral/complications
  • RNA, Untranslated
  • Renin-Angiotensin System
  • Transcriptome

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