Nonconventional MRI and microstructural cerebral changes in multiple sclerosis

Christian Enzinger, Frederik Barkhof, Olga Ciccarelli, Massimo Filippi, Ludwig Kappos, Maria A. Rocca, Stefan Ropele, Àlex Rovira, Torben Schneider, Nicola De Stefano, Hugo Vrenken, Claudia Wheeler-Kingshott, Jens Wuerfel, Franz Fazekas

Research output: Contribution to journalArticle

Abstract

MRI has become the most important paraclinical tool for diagnosing and monitoring patients with multiple sclerosis (MS). However, conventional MRI sequences are largely nonspecific in the pathology they reveal, and only provide a limited view of the complex morphological changes associated with MS. Nonconventional MRI techniques, such as magnetization transfer imaging (MTI), diffusion-weighted imaging (DWI) and susceptibility-weighted imaging (SWI) promise to complement existing techniques by revealing more-specific information on microstructural tissue changes. Past years have witnessed dramatic advances in the acquisition and analysis of such imaging data, and numerous studies have used these tools to probe tissue alterations associated with MS. Other MRI-based techniques-such as myelin-water imaging, 23 Na imaging, magnetic resonance elastography and magnetic resonance perfusion imaging-might also shed new light on disease-associated changes. This Review summarizes the rapid technical progress in the use of MRI in patients with MS, with a focus on nonconventional structural MRI. We critically discuss the present utility of nonconventional MRI in MS, and provide an outlook on future applications, including clinical practice. This information should allow appropriate selection of advanced MRI techniques, and facilitate their use in future studies of this disease.

Original languageEnglish
Pages (from-to)676-686
Number of pages11
JournalNature Reviews Neurology
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

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Multiple Sclerosis
Elasticity Imaging Techniques
Magnetic Resonance Angiography
Physiologic Monitoring
Myelin Sheath
Pathology
Water

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Nonconventional MRI and microstructural cerebral changes in multiple sclerosis. / Enzinger, Christian; Barkhof, Frederik; Ciccarelli, Olga; Filippi, Massimo; Kappos, Ludwig; Rocca, Maria A.; Ropele, Stefan; Rovira, Àlex; Schneider, Torben; De Stefano, Nicola; Vrenken, Hugo; Wheeler-Kingshott, Claudia; Wuerfel, Jens; Fazekas, Franz.

In: Nature Reviews Neurology, Vol. 11, No. 12, 01.12.2015, p. 676-686.

Research output: Contribution to journalArticle

Enzinger, C, Barkhof, F, Ciccarelli, O, Filippi, M, Kappos, L, Rocca, MA, Ropele, S, Rovira, À, Schneider, T, De Stefano, N, Vrenken, H, Wheeler-Kingshott, C, Wuerfel, J & Fazekas, F 2015, 'Nonconventional MRI and microstructural cerebral changes in multiple sclerosis', Nature Reviews Neurology, vol. 11, no. 12, pp. 676-686. https://doi.org/10.1038/nrneurol.2015.194
Enzinger, Christian ; Barkhof, Frederik ; Ciccarelli, Olga ; Filippi, Massimo ; Kappos, Ludwig ; Rocca, Maria A. ; Ropele, Stefan ; Rovira, Àlex ; Schneider, Torben ; De Stefano, Nicola ; Vrenken, Hugo ; Wheeler-Kingshott, Claudia ; Wuerfel, Jens ; Fazekas, Franz. / Nonconventional MRI and microstructural cerebral changes in multiple sclerosis. In: Nature Reviews Neurology. 2015 ; Vol. 11, No. 12. pp. 676-686.
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