Nondipping pattern and carotid atherosclerosis: A systematic review and meta-analysis

Cesare Cuspidi, Carla Sala, Marijana Tadic, Elisa Gherbesi, Guido Grassi, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


Evidence on the association of nondipping pattern with carotid atherosclerosis is scarce. We performed a meta-analysis in order to provide comprehensive information on subclinical carotid alterations in nondipping as compared with dipping individuals. A computerized search was performed using PubMed, OVID, EMBASE and Cochrane library databases from 1 January 1990 up to 31 March 2015. Full articles providing data on carotid intima-media thickness (IMT) and plaque in nondipping and dipping individuals, as assessed by ultrasonography, were analyzed. A total of 2753 adult individuals (1003 nondipping and 1750 dipping) included in 13 studies were considered. Common carotid IMT was higher in nondipping than in dipping individuals [807±36μm vs. 746±28μm, standard means difference, SMD: 0.37±0.09, confidence interval (CI): 0.19-0.56, P

Original languageEnglish
Pages (from-to)385-392
Number of pages8
JournalJournal of Hypertension
Issue number3
Publication statusPublished - Mar 1 2016


  • carotid atherosclerosis
  • nondipping
  • ultrasonography

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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