Nongastrointestinal mucosa-associated lymphoid tissue (MALT) lymphomas: Clinical and therapeutic features of 24 localized patients

P. L. Zinzani, M. Magagnoli, S. Ascani, P. Ricci, V. Poletti, F. Gherlinzoni, G. Frezza, M. Bendandi, C. Stefanetti, E. Merla, S. Pileri, S. Tura

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Background: Peripheral B-cell lymphoma of the marginal zone (MALT, low- grade), presenting as localized, extranodal disease, usually affects the elderly. The gastrointestinal tract is the most frequently involved extranodal location, representing 70% of all MALT lymphomas. Recently, numerous other extranodal sites involved by MALT lymphomas have also been described. Patients and methods: From January 1990 to October 1995, 24 patients with untreated nongastrointestinal low-grade MALT lymphoma were submitted to treatments ranging from the local approach of radiotherapy and local α-interferon (α-IFN) administration to chemotherapy. The tumours were located in the lung (seven cases), conjunctiva (four cases), lachrymal gland and orbital soft tissue (four cases), salivary glands (three cases), skin (three cases), breast (two cases), and thyroid (one case). All patients had low-grade stage IE tumours. Results: Chemotherapy was administered in 11 patients (six with lung, three with salivary gland, one with breast, and one with thyroid locations); radiation therapy was employed in seven patients (three with lachrymal gland, three with skin, and one with breast locations); local α-IFN administration was administered in five patients (four with conjunctival, and one with lachrymal gland sites); and surgery was employed in one patient with a lung tumour. All patients achieved complete remissions; three local recurrences and two relapses in other sites were observed. The global five-year survival rate was 100% with a relapse-free survival rate of 79%. Conclusions: These data confirm the significant efficacy of different therapeutic approaches to specific sites inbes obtaining a good remission rate for nongastrointestinal localized low-grade MALT lymphomas.

Original languageEnglish
Pages (from-to)883-886
Number of pages4
JournalAnnals of Oncology
Issue number9
Publication statusPublished - Sep 1997


  • α-Interferon
  • Low-grade MALT lymphoma
  • Non-gastrointestinal
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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