Nonhuman behavioral models in the genetics of disturbed behavior

Alberto Oliverio, Simona Cabib, Stefano Puglisi-Allegra

Research output: Contribution to journalArticle

Abstract

The development of the association method in which genetic markers match quantitative traits has led to quantitative trait loci (QTL) interval mapping. The association method has been extensively used in animal behavior genetics. Animal research allows more suitable linkage studies and detailed assessment of cellular and subcellular components of the central nervous system that may play a crucial role in the development susceptibility to behavioral disorders. Moreover, experimental designs in the laboratory setting allow genotype × environment interactions to be controlled, thus possibly providing more information on the role of nongenetic factors in gene expression. Experimental results are discussed which indicate that animal studies will provide a sort of test for hypotheses arising in clinical settings, allowing gene-product and product-behavior pathways to be examined at molecular levels when the gene accounts for a very small amount of genetic variance. In such a perspective, new molecular biology approaches and behavior genetics in nonhuman species could provide useful tools in the assessment of the genetic as well as nongenetic factors that lead to psychopathology.

Original languageEnglish
Pages (from-to)367-382
Number of pages16
JournalJournal of Psychiatric Research
Volume26
Issue number4
DOIs
Publication statusPublished - 1992

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Genetic Models
Choice Behavior
Animal Behavior
Quantitative Trait Loci
Psychopathology
Genetic Markers
Genes
Molecular Biology
Research Design
Central Nervous System
Genotype
Gene Expression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Nonhuman behavioral models in the genetics of disturbed behavior. / Oliverio, Alberto; Cabib, Simona; Puglisi-Allegra, Stefano.

In: Journal of Psychiatric Research, Vol. 26, No. 4, 1992, p. 367-382.

Research output: Contribution to journalArticle

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