Non–IgE-or mixed IgE/non–ige-mediated gastrointestinal food allergies in the first years of life: Old and new tools for diagnosis

Mauro Calvani; Caterina Anania; Barbara Cuomo; Enza D’auria; Fabio Decimo; Giovanni Cosimo Indirli; Gianluigi Marseglia; Violetta Mastrorilli; Marco Ugo Andrea Sartorio; Angelica Santoro; Elisabetta Veronelli

doi:10.3390/nu13010226

Non–IgE-or mixed IgE/non–ige-mediated gastrointestinal food allergies in the first years of life: Old and new tools for diagnosis

Mauro Calvani, Caterina Anania, Barbara Cuomo, Enza D’auria, Fabio Decimo, Giovanni Cosimo Indirli, Gianluigi Marseglia, Violetta Mastrorilli, Marco Ugo Andrea Sartorio, Angelica Santoro, Elisabetta Veronelli

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Review article › peer-review

Abstract

non-IgE and mixed gastrointestinal food allergies present various specific, well-characterized clinical pictures such as food protein-induced allergic proctocolitis, food protein-induced enterocolitis and food protein-induced enteropathy syndrome as well as eosinophilic gastrointestinal disorders such as eosinophilic esophagitis, allergic eosinophilic gastroenteritis and eosinophilic colitis. The aim of this article is to provide an updated review of their different clinical presentations, to suggest a correct approach to their diagnosis and to discuss the usefulness of both old and new diagnostic tools, including fecal biomarkers, atopy patch tests, endoscopy, specific IgG and IgG4 testing, allergenspecific lymphocyte stimulation test (ALST) and clinical score (CoMiss).

Original language	English
Article number	226
Pages (from-to)	1-31
Number of pages	31
Journal	Nutrients
Volume	13
Issue number	1
DOIs	https://doi.org/10.3390/nu13010226
Publication status	Published - Jan 2021

Keywords

Allergen-specific lymphocyte stimulation test
Atopy patch test
Clinical score
Endoscopy
Eosinophilic gastrointestinal disorders
Fecal biomarkers
IgG and IgG4
Non-IgE gastrointestinal food allergy
Oral food challenge

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

Access to Document

10.3390/nu13010226

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Non–IgE-or mixed IgE/non–ige-mediated gastrointestinal food allergies in the first years of life : Old and new tools for diagnosis. / Calvani, Mauro; Anania, Caterina; Cuomo, Barbara; D’auria, Enza; Decimo, Fabio; Indirli, Giovanni Cosimo; Marseglia, Gianluigi; Mastrorilli, Violetta; Sartorio, Marco Ugo Andrea; Santoro, Angelica; Veronelli, Elisabetta.

In: Nutrients, Vol. 13, No. 1, 226, 01.2021, p. 1-31.

Research output: Contribution to journal › Review article › peer-review

Calvani, Mauro ; Anania, Caterina ; Cuomo, Barbara ; D’auria, Enza ; Decimo, Fabio ; Indirli, Giovanni Cosimo ; Marseglia, Gianluigi ; Mastrorilli, Violetta ; Sartorio, Marco Ugo Andrea ; Santoro, Angelica ; Veronelli, Elisabetta. / Non–IgE-or mixed IgE/non–ige-mediated gastrointestinal food allergies in the first years of life : Old and new tools for diagnosis. In: Nutrients. 2021 ; Vol. 13, No. 1. pp. 1-31.

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abstract = "non-IgE and mixed gastrointestinal food allergies present various specific, well-characterized clinical pictures such as food protein-induced allergic proctocolitis, food protein-induced enterocolitis and food protein-induced enteropathy syndrome as well as eosinophilic gastrointestinal disorders such as eosinophilic esophagitis, allergic eosinophilic gastroenteritis and eosinophilic colitis. The aim of this article is to provide an updated review of their different clinical presentations, to suggest a correct approach to their diagnosis and to discuss the usefulness of both old and new diagnostic tools, including fecal biomarkers, atopy patch tests, endoscopy, specific IgG and IgG4 testing, allergenspecific lymphocyte stimulation test (ALST) and clinical score (CoMiss).",

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