Noninducibility in postinfarction ventricular tachycardia as an end point for ventricular tachycardia ablation and its effects on outcomes a meta-analysis

Hamid Ghanbari, Kazim Baser, Miki Yokokawa, William Stevenson, Paolo Della Bella, Pasquale Vergara, Thomas Deneke, Karl Heinz Kuck, Hans Kottkamp, She Fei, Fred Morady, Frank Bogun

Research output: Contribution to journalArticle

Abstract

Background-Although ventricular tachycardia (VT) ablation is a widely used therapy for patients with VT, the ideal end points for this procedure are not well defined. We performed a meta-analysis of the published literature to assess the predictive value of noninducibility of postinfarction VT for long-term outcomes after VT ablation.Methods and Results-We performed a systematic review of MEDLINE (1950-2013), EMBASE (1988-2013), the Cochrane Controlled Trials Register (Fourth Quarter, 2012), and reports presented at scientific meetings (1994-2013). Randomized controlled trials, case-control, and cohort studies of VT ablation were included. Outcomes reported in eligible studies were freedom from VT/ventricular fibrillation and all-cause mortality. Of the 3895 studies evaluated, we identified 8 cohort studies enrolling 928 patients for the meta-analysis. Noninducibility after VT ablation was associated with a significant increase in arrhythmia-free survival compared with partial success (odds ratio, 0.49; 95% confidence interval, 0.29-0.84; P=0.009) or failed ablation procedure (odds ratio, 0.10; 95% confidence interval, 0.06-0.18; P

Original languageEnglish
Pages (from-to)677-683
Number of pages7
JournalCirculation: Arrhythmia and Electrophysiology
Volume7
Issue number4
DOIs
Publication statusPublished - Aug 1 2014

Keywords

  • Meta-analysis
  • Tachycardia
  • Ventricular

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Medicine(all)

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