TY - JOUR
T1 - Noninvasive assessment of breast cancer risk using time-resolved diffuse optical spectroscopy
AU - Taroni, Paola
AU - Pifferi, Antonio
AU - Quarto, Giovanna
AU - Spinelli, Lorenzo
AU - Torricelli, Alessandro
AU - Abbate, Francesca
AU - Villa, Anna
AU - Balestreri, Nicola
AU - Menna, Simona
AU - Cassano, Enrico
AU - Cubeddu, Rinaldo
PY - 2010/11
Y1 - 2010/11
N2 - Breast density is a recognized strong and independent risk factor for breast cancer. We propose the use of time-resolved transmittance spectroscopy to estimate breast tissue density and potentially provide even more direct information on breast cancer risk. Time-resolved optical mammography at seven wavelengths (635 to 1060 nm) is performed on 49 subjects. Average information on breast tissue of each subject is obtained on oxy- and deoxyhemoglobin, water, lipids, and collagen content, as well as scattering amplitude and power. All parameters, except for blood volume and oxygenation, correlate with mammographic breast density, even if not to the same extent. A synthetic optical index proves to be quite effective in separating different breast density categories. Finally, the estimate of collagen content as a more direct means for the assessment of breast cancer risk is discussed.
AB - Breast density is a recognized strong and independent risk factor for breast cancer. We propose the use of time-resolved transmittance spectroscopy to estimate breast tissue density and potentially provide even more direct information on breast cancer risk. Time-resolved optical mammography at seven wavelengths (635 to 1060 nm) is performed on 49 subjects. Average information on breast tissue of each subject is obtained on oxy- and deoxyhemoglobin, water, lipids, and collagen content, as well as scattering amplitude and power. All parameters, except for blood volume and oxygenation, correlate with mammographic breast density, even if not to the same extent. A synthetic optical index proves to be quite effective in separating different breast density categories. Finally, the estimate of collagen content as a more direct means for the assessment of breast cancer risk is discussed.
KW - absorption
KW - breast cancer
KW - breast density
KW - scattering
KW - tissue spectroscopy
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U2 - 10.1117/1.3506043
DO - 10.1117/1.3506043
M3 - Article
C2 - 21198142
AN - SCOPUS:78650110251
VL - 15
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
SN - 1083-3668
IS - 6
M1 - 060501
ER -