Noninvasive assessment of coronary anatomy and myocardial perfusion: Going toward an integrated imaging approach

Mario Petretta, Pierluigi Costanzo, Wanda Acampa, Massimo Imbriaco, Adele Ferro, Pasquale Perrone Filardi, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review


Many noninvasive imaging techniques are available for the evaluation of patients with known or suspected chronic coronary artery disease. Among these, computed tomography-based techniques allow the quantification of coronary atherosclerotic calcium and noninvasive imaging of coronary arteries, whereas nuclear cardiology is the most widely used noninvasive approach for the assessment of myocardial perfusion. The available single-photon emission computed tomography flow agents are characterized by a cardiac uptake proportional to myocardial blood flow. In addition, different positron emission tomography tracers may be used for the quantitative measurement of myocardial blood flow and coronary flow reserve. Extensive research is currently being performed in the development of noninvasive coronary angiography and myocardial perfusion imaging using cardiac magnetic resonance. Finally, new multimodality imaging systems have been recently developed, bringing together anatomical and functional information. This review sought to provide a description of the relative merits of noninvasive imaging techniques in the assessment of coronary anatomy and myocardial perfusion in patients with known or suspected coronary artery disease.

Original languageEnglish
Pages (from-to)977-986
Number of pages10
JournalJournal of Cardiovascular Medicine
Issue number10
Publication statusPublished - Oct 2008


  • Coronary anatomy
  • Coronary artery disease
  • Myocardial perfusion
  • Noninvasive imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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