Most of this investigation deals with descriptive phenomena; we now have a partial profile of the biophysical events in psoriasis, as well as their expected return toward normality with successful pharmacologic therapy. What we clearly need is use of this database to develop therapeutic interventions that are valuable to the psoriatic. What might be reasonably accomplished? Although many possibilities exist, one practical approach would document the returning of the parameter investigated to normal, possibly predictive of a therapeutic result. Currently we wait at least 1 week before altering a therapeutic regimen based on lesion morphology and patient preference. It is possible that a biophysical signal of skin function might predict management change in days rather than weeks. Lesion blood flow after treatment plummets towards normality in about 48 hours. Should we monitor lesion blood flow at this time to seek predictions of eventual efficacy? In a chronic and discomforting disease like psoriasis, a rational approach of this type surely deserves attention.
|Number of pages||4|
|Journal||International Journal of Dermatology|
|Publication status||Published - 1989|
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